An antagonistic interaction between adenosine A1 and dopamine D1 receptors has
previously been found in the basal ganglia. However, direct evidence for a selective …

BEHAVIOURAL, AND biochemical evidence for the existence of a powerful specific
postsynaptic interaction between adenosine A 1, and dopamine D 1 receptors in the …

Antagonistic interactions between adenosine A2a and dopamine D2 receptors and between
adenosine A1 and dopamine D1 receptors have been previously found in the basal ganglia …

Dopamine D2 and adenosine A2A receptors interact to regulate aspects of motor and
motivational function, and it has been suggested that adenosine A2A antagonists could be …

It has been shown that striatal adenosine A2A receptors can antagonistically interact with
dopamine D2 receptors at the membrane level leading to a decrease in the affinity and …

A cDNA fragment homologous to other G protein-coupled receptors was isolated from rat
brain using the PCR method and demonstrated to be abundantly expressed in striatum …

Forebrain dopamine (DA) is a critical component of the brain circuitry regulating behavioral
activation. Adenosine A2A antagonists reverse many of the behavioral effects of DA …

Since high-affinity adenosine A2 receptors (A2a) are localized exclusively in dopamine-rich
regions in the central nervous system and mediate inhibition of locomotor activity, we have …

In Parkinson's disease a degeneration of dopaminergic neurons of the nigrostriatal pathway
is observed. Loss of dopaminergic regulation of striatal neuron activity results in altered …

Adenosine and dopamine receptors in striatal areas interact to regulate a number of different
functions, including aspects of motor control and motivation. Recent studies indicate that …