Environmental epigenetic regulation in asthma and allergic disease is an exciting area that
has gained a great deal of scientific momentum in recent years. Environmental exposures …

abstract Bronchial asthma is characterized by persistent cough, increased sputum, and
repeated wheezing. The pathophysiology underlying these symptoms is the hyper …

Allergic sensitization to inhaled antigens is common but poorly understood. Although lung
epithelial cells were initially merely regarded as a passive barrier impeding allergen …

Although asthma is an inflammatory disorder of the conducting airways involving TH2-type T
cells, there is increasing evidence for an important role played by the epithelium in …

Epithelial cells in the airway wall actively interact with environmental antigens/allergens,
both in healthy individuals and patients with asthma. In patients with (allergic) asthma, the …

BACKGROUND: Asthma is a complex disease involving gene and environment interactions.
Although atopy is a strong predisposing risk factor for asthma, local tissue susceptibilities …

The type 2 cytokine-high asthma endotype (T2H) is characterized by IL-13-driven mucus
obstruction of the airways. To further investigate this incompletely understood pathobiology …

Asthma is a chronic disease of the airways characterized by inflammation, tightened
muscles, and thickened airway walls leading to symptoms such as shortness of breath, chest …

Allergic bronchial asthma is a chronic disease of the airways that is characterized by
symptoms like respiratory distress, chest tightness, wheezing, productive cough, and acute …

Asthma and eczema (atopic dermatitis) are the most common chronic diseases of childhood.
These diseases are characterized by the production of high levels of immunoglobulin E in …