The major function of the respiratory epithelium was once thought to be that of a physical
barrier. However, it constitutes the interface between the internal milieu and the external …

The community of cells lining our airways plays a collaborative role in the preservation of
immune homeostasis in the lung and provides protection from the pathogens and pollutants …

Exaggerated airway hyperresponsiveness and inflammation are hallmarks of asthma, and
lipopolysaccharide (LPS) exposure is linked to the severity of the disease and steroid …

Background In allergic asthma, IgE increases airway remodelling but the mechanism is
incompletely understood. Airway remodelling consists of two independent events increased …

Background: Type 2 (T2) inflammation drives airway dysfunction in many patients with
asthma; yet, we lack a comprehensive understanding of the airway immune cell types and …

Rationale: Quantification of type 2 inflammation provided a molecular basis for
heterogeneity in asthma. Non–type 2 pathways that contribute to asthma pathogenesis are …

Allergic rhinitis (AR), chronic rhinosinusitis (CRS) and asthma often co‐exist. The one airway
model proposes that disease mechanisms occurring in the upper airway may mirror lower …

Many patients suffering from asthma are not fully controlled by currently available
treatments, and some of them display an airway remodeling leading to exaggerated lung …

Asthma and allergic rhinitis frequently coexist in the same patient. There is a similarity and
variation as well as potential relationship between asthma and allergic rhinitis. There is an …

Background The small airway epithelium (SAE), the cell population that covers the human
airway surface from the 6 th generation of airway branching to the alveoli, is the major site of …