Acral melanoma (AM) is an aggressive melanoma variant that arises from palmar, plantar,
and nail unit melanocytes. Compared to non-acral cutaneous melanoma (CM), AM is …

Acral melanoma (AM) is a rare subtype of melanoma characterized by a high incidence of
lymph node (LN) metastasis, a critical factor in tumor dissemination and therapeutic decision …

Purpose: Acral melanoma is a rare subtype of melanoma that arises on the non–hair-
bearing skin of the palms, soles, and nail beds. In this study, we used single-cell RNA …

Background Acral melanoma is a rare type of melanoma that affects world populations
irrespective of skin color and has worse survival than other cutaneous melanomas. It has …

Genomic analyses of cutaneous melanoma (CM) have yielded biological and therapeutic
insights, but understanding of non-ultraviolet (UV)-derived CMs remains limited. Deeper …

Acral melanoma is an aggressive type of melanoma with unknown origins, arising on the
sole, palm, or nail apparatus. It is the most common type of melanoma in individuals with …

Ultraviolet radiation (UV) is causally linked to cutaneous melanoma, yet the underlying
epigenetic mechanisms, known as molecular sensors of exposure, have not been …

In acral melanoma (AM), progression from in situ (AMis) to invasive AM (iAM) leads to
significantly reduced survival. However, evolutionary dynamics during this process remain …

More than half of metastatic melanoma patients receiving standard therapy fail to achieve a
long-term survival due to primary and/or acquired resistance. Tumor cell ability to switch …

Acral melanoma is more biologically aggressive with a worse prognosis compared with
other melanoma subtypes. However, the molecular basis underlying the biological and …