Machine learning-enabled predictive modeling to precisely identify the antimicrobial peptides
The ubiquitous antimicrobial peptides (AMPs), with a broad range of antimicrobial activities,
represent a great promise for combating the multi-drug resistant infections. In this study …
represent a great promise for combating the multi-drug resistant infections. In this study …
[HTML][HTML] Accelerated antimicrobial discovery via deep generative models and molecular dynamics simulations
The de novo design of antimicrobial therapeutics involves the exploration of a vast chemical
repertoire to find compounds with broad-spectrum potency and low toxicity. Here, we report …
repertoire to find compounds with broad-spectrum potency and low toxicity. Here, we report …
A Computationally Designed Peptide Derived from Escherichia coli as a Potential Drug Template for Antibacterial and Antibiofilm Therapies
MH Cardoso, ES Candido, LY Chan… - ACS infectious …, 2018 - ACS Publications
Computer-aided screening of antimicrobial peptides (AMPs) is a promising approach for
discovering novel therapies against multidrug-resistant bacterial infections. Here, we …
discovering novel therapies against multidrug-resistant bacterial infections. Here, we …
Collection of antimicrobial peptides database and its derivatives: Applications and beyond
FH Waghu, S Idicula‐Thomas - Protein Science, 2020 - Wiley Online Library
Collection of antimicrobial peptides (CAMP), CAMPSign, and ClassAMP are open‐access
resources that have been developed to enhance research on antimicrobial peptides (AMPs) …
resources that have been developed to enhance research on antimicrobial peptides (AMPs) …
Comprehensive assessment of machine learning-based methods for predicting antimicrobial peptides
Antimicrobial peptides (AMPs) are a unique and diverse group of molecules that play a
crucial role in a myriad of biological processes and cellular functions. AMP-related studies …
crucial role in a myriad of biological processes and cellular functions. AMP-related studies …
DBAASP v. 2: an enhanced database of structure and antimicrobial/cytotoxic activity of natural and synthetic peptides
Antimicrobial peptides (AMPs) are anti-infectives that may represent a novel and untapped
class of biotherapeutics. Increasing interest in AMPs means that new peptides (natural and …
class of biotherapeutics. Increasing interest in AMPs means that new peptides (natural and …
Machine learning-enabled discovery and design of membrane-active peptides
Antimicrobial peptides are a class of membrane-active peptides that form a critical
component of innate host immunity and possess a diversity of sequence and structure …
component of innate host immunity and possess a diversity of sequence and structure …
[HTML][HTML] Analysis and prediction of the critical regions of antimicrobial peptides based on conditional random fields
KY Chang, T Lin, LY Shih, CK Wang - PloS one, 2015 - journals.plos.org
Antimicrobial peptides (AMPs) are potent drug candidates against microbes such as
bacteria, fungi, parasites, and viruses. The size of AMPs ranges from less than ten to …
bacteria, fungi, parasites, and viruses. The size of AMPs ranges from less than ten to …
Computational design of highly selective antimicrobial peptides
We have created a structure-selectivity database (AMPad) of frog-derived, helical
antimicrobial peptides (AMPs), in which the selectivity was determined as a therapeutic …
antimicrobial peptides (AMPs), in which the selectivity was determined as a therapeutic …
The structure/function relationship in antimicrobial peptides: what can we obtain from structural data?
Antimicrobial peptides (AMPs) have been widely isolated from most organisms in nature.
This class of antimicrobials may undergo changes in their sequence for improved …
This class of antimicrobials may undergo changes in their sequence for improved …