Obesity is associated with an increased risk of developing insulin resistance and type 2
diabetes. In obese individuals, adipose tissue releases increased amounts of non-esterified …

An insidious increase in features of the'metabolic syndrome'—obesity, insulin resistance and
dyslipidaemia—has conspired to produce a worldwide epidemic of type 2 insulin-resistant …

Type 2 diabetes is a complex metabolic disorder characterized by peripheral insulin
resistance and impaired Β cell function 1, 2. Insulin resistance is inherited as a non …

An appropriate β cell mass is pivotal for the maintenance of glucose homeostasis. Both
insulin and IGF-1 are important in regulation of β cell growth and function (reviewed in ref.) …

The humoral side of insulin resistance | Nature Medicine Skip to main content Thank you for
visiting nature.com. You are using a browser version with limited support for CSS. To obtain the …

The pathways that control insulin secretion and regulate pancreatic β-cell mass are crucial
in the development of diabetes mellitus. Maturity-onset diabetes of the young comprises a …

The epidemic of type 2 diabetes and impaired glucose tolerance is one of the main causes
of morbidity and mortality worldwide. In both disorders, tissues such as muscle, fat and liver …

Nutritional excess is a major forerunner of type 2 diabetes. It enhances the secretion of
insulin, but attenuates insulin's metabolic actions in the liver, skeletal muscle and adipose …

The epidemic of obesity-associated diabetes is a major crisis in modern societies, in which
food is plentiful and exercise is optional. The biological basis of this problem has been …

The relative contributions of insulin resistance and beta-cell dysfunction to the
pathophysiology of Type 2 diabetes have been debated extensively. The concept that a …