The direct injection of endothelin‐1 (ET‐1) into brain parenchyma was recently suggested
as a suitable model of stroke. The present study was designed to assess whether …

The goal of this study was to develop a new model of ischemia‐induced seizures in
immature rats using injection of vasoconstrictor Endothelin‐1 (ET‐1) into the brain. ET‐1 (10 …

In a model of focal cerebral ischemia in mice, intracisternal injection of 5 and 10 pmol/mouse
endothelin-1 significantly increased the infarcted surface area by 15.5% and by 23.5 …

The aim was to test the hypothesis that occlusion of the middle cerebral artery (MCA) results
in the development of epilepsy in rats. Further, we investigated whether lesion volume …

Intracerebral injection of the vasoconstrictor peptide, endothelin-1 (ET-1), has been used as
a method to induce focal ischemia in rats. The relative technical simplicity of this model …

The present study examines the possibility that lesions induced by intrastriatal injections of
endothelin-1 (ET-1, 0.43 nmol/0.5 µl) are ischemic in nature due to a vasoconstriction of the …

Endothelin 1 (ET-1) exerts normally a powerful vasoconstrictor role in the control of the brain
microcirculation. In altered states, such as following traumatic brain injury (TBI), it may …

10 L.-S Loo, Y.-K Ng, Y.-Z Zhu, H.-S Lee, PT-H Wong, Cortical expression of endothelin
receptor subtypes A and B following middle cerebral artery occlusion in rats, Neuroscience …

The powerful vasoconstrictor peptide endothelin-1 (ET1) has been shown to reduce local
cerebral blood flow in brain areas supplied by the middle cerebral artery (MCA) to a …

We investigated the effect of small cortical ischemic lesions, produced by intracerebral
injection of the vasoconstrictor endothelin-1, on neurogenesis in the adult mouse …