[HTML][HTML] Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer's disease

AR Nelson, MD Sweeney, AP Sagare… - Biochimica et Biophysica …, 2016 - Elsevier
Vascular insults can initiate a cascade of molecular events leading to neurodegeneration,
cognitive impairment, and dementia. Here, we review the cellular and molecular …

[HTML][HTML] Vascular contributions to cognitive impairment, clinical Alzheimer's disease, and dementia in older persons

A Kapasi, JA Schneider - Biochimica et Biophysica Acta (BBA)-Molecular …, 2016 - Elsevier
There is growing evidence suggesting that vascular pathologies and dysfunction play a
critical role in cognitive impairment, clinical Alzheimer's disease, and dementia. Vascular …

Neurovascular mechanisms of Alzheimer's neurodegeneration

BV Zlokovic - Trends in neurosciences, 2005 - cell.com
In contrast to traditional neuroncentric views of Alzheimer's disease (AD), recent findings
indicate that neurovascular dysfunction contributes to cognitive decline and …

Dissecting the contribution of vascular alterations and aging to Alzheimer's disease

C Janota, CA Lemere, MA Brito - Molecular neurobiology, 2016 - Springer
Alzheimer's disease (AD) is a neurodegenerative disease characterized by cognitive decline
that afflicts as many as 45% of individuals who survive past the age of 85. AD has been …

Neurovascular dysfunction and faulty amyloid β-peptide clearance in Alzheimer disease

AP Sagare, RD Bell… - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
Neurovascular dysfunction is an integral part of Alzheimer disease (AD). Changes in the
brain vascular system may contribute in a significant way to the onset and progression of …

The neurovascular unit in brain function and disease

C Lecrux, E Hamel - Acta physiologica, 2011 - Wiley Online Library
Neurovascular coupling, or functional hyperaemia, refers to complex mechanisms of
communication between neurons, astrocytes and cerebral vessels which form the …

Neurovascular defects and faulty amyloid-β vascular clearance in Alzheimer's disease

AP Sagare, RD Bell, BV Zlokovic - Journal of Alzheimer's …, 2013 - content.iospress.com
The evidence that neurovascular dysfunction is an integral part of Alzheimer's disease (AD)
pathogenesis has continued to emerge in the last decade. Changes in the brain vasculature …

Neurovascular mechanisms and blood–brain barrier disorder in Alzheimer's disease

RD Bell, BV Zlokovic - Acta neuropathologica, 2009 - Springer
Vascular dysfunction has a critical role in Alzheimer's disease (AD). Recent data from brain
imaging studies in humans and animal models suggest that cerebrovascular dysfunction …

Endothelial dysfunction and amyloid-β-induced neurovascular alterations

K Koizumi, G Wang, L Park - Cellular and molecular neurobiology, 2016 - Springer
Alzheimer's disease (AD) and cerebrovascular diseases share common vascular risk factors
that have disastrous effects on cerebrovascular regulation. Endothelial cells, lining inner …

New therapeutic targets in the neurovascular pathway in Alzheimer's disease

BV Zlokovic - Neurotherapeutics, 2008 - Springer
Recent findings indicate that neurovascular dysfunction is an integral part of Alzheimer's
disease (AD). Changes in the vascular system of the brain may significantly contribute to the …