TET proteins safeguard bivalent promoters from de novo methylation in human embryonic stem cells
Abstract TET enzymes oxidize 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC),
which can lead to DNA demethylation. However, direct connections between TET-mediated …
which can lead to DNA demethylation. However, direct connections between TET-mediated …
[HTML][HTML] Tet3 regulates cellular identity and DNA methylation in neural progenitor cells
M Santiago, C Antunes, M Guedes, M Iacovino… - Cellular and Molecular …, 2020 - Springer
Abstract TET enzymes oxidize 5-methylcytosine (5mC) into 5-hydroxymethylcytosine
(5hmC), a process thought to be intermediary in an active DNA demethylation mechanism …
(5hmC), a process thought to be intermediary in an active DNA demethylation mechanism …
TET1 is a maintenance DNA demethylase that prevents methylation spreading in differentiated cells
TET1 is a 5-methylcytosine dioxygenase and its DNA demethylating activity has been
implicated in pluripotency and reprogramming. However, the precise role of TET1 in DNA …
implicated in pluripotency and reprogramming. However, the precise role of TET1 in DNA …
TET enzymes, DNA demethylation and pluripotency
SE Ross, O Bogdanovic - Biochemical Society Transactions, 2019 - portlandpress.com
Ten-eleven translocation (TET) methylcytosine dioxygenases (TET1, TET2, TET3) actively
cause demethylation of 5-methylcytosine (5mC) and produce and safeguard …
cause demethylation of 5-methylcytosine (5mC) and produce and safeguard …
Tet1 and Tet2 protect DNA methylation canyons against hypermethylation
L Wiehle, G Raddatz, T Musch… - … and cellular biology, 2016 - Taylor & Francis
DNA methylation is a dynamic epigenetic modification with an important role in cell fate
specification and reprogramming. The Ten eleven translocation (Tet) family of enzymes …
specification and reprogramming. The Ten eleven translocation (Tet) family of enzymes …
[HTML][HTML] Genome-wide regulation of 5hmC, 5mC, and gene expression by Tet1 hydroxylase in mouse embryonic stem cells
DNA methylation at the 5 position of cytosine (5mC) in the mammalian genome is a key
epigenetic event critical for various cellular processes. The ten-eleven translocation (Tet) …
epigenetic event critical for various cellular processes. The ten-eleven translocation (Tet) …
Tet enzymes are essential for early embryogenesis and completion of embryonic genome activation
Mammalian development begins in transcriptional silence followed by a period of
widespread activation of thousands of genes. DNA methylation reprogramming is integral to …
widespread activation of thousands of genes. DNA methylation reprogramming is integral to …
TETs compete with DNMT3 activity in pluripotent cells at thousands of methylated somatic enhancers
J Charlton, EJ Jung, AL Mattei, N Bailly, J Liao… - Nature …, 2020 - nature.com
Mammalian cells stably maintain high levels of DNA methylation despite expressing both
positive (DNMT3A/B) and negative (TET1-3) regulators. Here, we analyzed the independent …
positive (DNMT3A/B) and negative (TET1-3) regulators. Here, we analyzed the independent …
[HTML][HTML] Loss of Tet enzymes compromises proper differentiation of embryonic stem cells
MM Dawlaty, A Breiling, T Le, MI Barrasa, G Raddatz… - Developmental cell, 2014 - cell.com
Summary Tet enzymes (Tet1/2/3) convert 5-methylcytosine (5mC) to 5-
hydroxymethylcytosine (5hmC) and are dynamically expressed during development …
hydroxymethylcytosine (5hmC) and are dynamically expressed during development …
Tet1 and 5-hydroxymethylation: a genome-wide view in mouse embryonic stem cells
Inner cell mass (ICM) cells of a blastocyst, the source of embryonic stem (ES) cells, are
characterized by their unique ability to give rise to all cell types in adult organisms. The …
characterized by their unique ability to give rise to all cell types in adult organisms. The …