Protein kinases are critical to cellular signalling and post-translational gene regulation, but
their biological substrates are difficult to identify. We show that cyclin-dependent kinase …

Cyclin-dependent kinases (CDKs) are involved in many crucial processes, such as cell cycle
and transcription, as well as communication, metabolism, and apoptosis. The kinases are …

Cyclin-dependent kinases (CDKs) play essential roles in coordinate control of cell cycle
progression. Activation of CDKs requires interaction with specific cyclin partners and …

A family of conserved serine/threonine kinases known as cyclin-dependent kinases (CDKs)
drives orderly cell cycle progression in mammalian cells. Prior studies have suggested that …

In the past decade, the discovery and characterization of cyclin-dependent kinases (CDKs),
the engine cores of the cell cycle machinery, have advanced our understanding of the cell …

After a decade of extensive work on gene knockout mouse models of cell-cycle regulators,
the classical model of cell-cycle regulation was seriously challenged. Several unexpected …

Cyclin-dependent protein kinases (CDKs) play key roles in the progression of the cell cycle
in eukaryotes. A CDK-activating kinase (CAK) catalyzes the phosphorylation of CDKs to …

Cyclin-dependent protein kinases (Cdks) play key roles in regulating cell division and gene
expression. Most Cdks require binding of a cyclin and phosphorylation by a Cdk-activating …

Our current understanding of the eukaryotic cell cycle attributes a key regulatory role to
cyclin-dependent protein kinases. It is important, therefore, to identify the physiological …

The roles of cyclins and their catalytic partners, the cyclin-dependent kinases (CDKs), as
core components of the machinery that drives cell cycle progression are well established …