G protein-coupled receptors (GPCRs) are integral membrane proteins that transduce a wide
array of inputs including light, ions, hormones, and neurotransmitters into intracellular …

Recent technical and conceptual advances in lipid analysis have given us a glimpse into the
true versatility of the lipidome and the complexity of lipid signaling species. Progress alike in …

Cholesterol is essential for cell physiology. Transport of the “accessible” pool of cholesterol
from the plasma membrane (PM) to the endoplasmic reticulum (ER) by ER‐localized …

The cardiovascular system is richly endowed with G protein–coupled receptors (GPCRs),
members of the largest family of plasma membrane-localized receptors. During the last 10 …

G protein-coupled receptors (GPCRs) are the major drug target of medicines on the market
today. Therefore, much research is and has been devoted to the elucidation of the function …

Cholesterol is a key component of cell membranes with a proven modulatory role on the
function and ligand-binding properties of G-protein-coupled receptors (GPCRs). Crystal …

As described in the literature the interaction between cholesterol and membrane proteins
can occur via direct, ligand-like and indirect mechanisms, in which cholesterol effects are …

The role of cholesterol in eukaryotic membrane protein function has been attributed primarily
to an influence on membrane fluidity and curvature. We present the 2.8 Å resolution crystal …

G protein-coupled receptors (GPCRs) constitute a superfamily of cell-surface receptors
which share a common topology of seven transmembrane domains and modulate a variety …

Cholesterol, an abundant membrane component in both lipid rafts and caveolae of cell
membrane, plays a crucial role in regulating the function and organization of various G …