Association of mutations in the zona pellucida binding protein 1 (ZPBP1) gene with abnormal sperm head morphology in infertile men

AN Yatsenko, DS O'Neil, A Roy… - Molecular human …, 2012 - academic.oup.com
Nearly 7% of men are afflicted by male infertility worldwide, and genetic factors are
suspected to play a significant role in the majority of these patients. Although sperm …

Loss of zona pellucida binding proteins in the acrosomal matrix disrupts acrosome biogenesis and sperm morphogenesis

YN Lin, A Roy, W Yan, KH Burns… - Molecular and cellular …, 2007 - Taylor & Francis
Zona pellucida binding protein 1 (ZPBP1), a spermatid and spermatozoon protein that
localizes to the acrosome, was originally identified in pigs and named for its binding to the …

Identification of sperm head proteins involved in zona pellucida binding

FM Petit, C Serres, F Bourgeon, C Pineau… - Human …, 2013 - academic.oup.com
STUDY QUESTION Which human sperm proteins interact with zona pellucida (ZP)
glycoproteins, ZPA/2, ZPB/4 and ZPC/3? SUMMARY ANSWER Co-precipitation experiments …

Novel mutations in ZP1, ZP2, and ZP3 cause female infertility due to abnormal zona pellucida formation

Z Zhou, C Ni, L Wu, B Chen, Y Xu, Z Zhang, J Mu, B Li… - Human Genetics, 2019 - Springer
The human zona pellucida (ZP) is an extracellular glycoprotein matrix composed of ZP1,
ZP2, ZP3, and ZP4 surrounding the oocyte, and it plays an important role in sperm–egg …

Mutations in ZP4 are associated with abnormal zona pellucida and female infertility

X Wei, Y Li, Q Liu, W Liu, X Yan, X Zhu… - Journal of Clinical …, 2022 - jcp.bmj.com
Background The zona pellucida (ZP) of human oocytes plays essential protective roles in
sperm–egg interactions during fertilisation and embryo development. ZP4-null female …

The multi PDZ domain protein MUPP1 as a putative scaffolding protein for organizing signaling complexes in the acrosome of mammalian spermatozoa

D Heydecke, D Meyer, F Ackermann… - Journal of …, 2006 - Wiley Online Library
Spermatozoa undergo complex sequences of precisely timed events during the process of
fertilization. These priming events, which comprise capacitation, egg recognition, acrosome …

Dosage effects of ZP2 and ZP3 heterozygous mutations cause human infertility

W Liu, K Li, D Bai, J Yin, Y Tang, F Chi, L Zhang… - Human Genetics, 2017 - Springer
The zona pellucida (ZP) is an extracellular matrix universally surrounding mammalian eggs,
which is essential for oogenesis, fertilization, and pre-implantation embryo development …

[HTML][HTML] A newly discovered mutation in PICK1 in a human with globozoospermia

G Liu, QW Shi, GX Lu - Asian journal of andrology, 2010 - ncbi.nlm.nih.gov
Globozoospermia is a human infertility syndrome caused by spermatogenesis defects
(OMIM 102530). Acrosome plays an important role at the site of sperm-zonapellucida …

[HTML][HTML] Human zona pellucida glycoproteins: binding characteristics with human spermatozoa and induction of acrosome reaction

SK Gupta - Frontiers in cell and developmental biology, 2021 - frontiersin.org
Human zona pellucida (ZP) matrix is composed of four glycoproteins designated as ZP
glycoprotein-1 (ZP1),-2 (ZP2),-3 (ZP3), and-4 (ZP4). Mutations in the genes encoding human …

[HTML][HTML] 'ZP domain'of human zona pellucida glycoprotein-1 binds to human spermatozoa and induces acrosomal exocytosis

A Ganguly, P Bansal, T Gupta, SK Gupta - Reproductive Biology and …, 2010 - Springer
Background The human egg coat, zona pellucida (ZP), is composed of four glycoproteins
designated as zona pellucida glycoprotein-1 (ZP1),-2 (ZP2),-3 (ZP3) and-4 (ZP4) …