Epiregulin is up-regulated in pancreatic cancer and stimulates pancreatic cancer cell growth

Z Zhu, J Kleeff, H Friess, L Wang… - Biochemical and …, 2000 - Elsevier
Epiregulin belongs to the epidermal growth factor (EGF) family of polypeptides. Previous
studies have underscored the important role of the EGF family of ligands and receptors in …

Distribution of mRNA for human epiregulin, a differentially expressed member of the epidermal growth factor family

H TOYODA, T KOMURASAKI, D UCHIDA… - Biochemical …, 1997 - portlandpress.com
We have recently identified epiregulin as a new growth regulator and a member of the
epidermal growth factor (EGF) family. Epiregulin has certain characteristics that are different …

Epiregulin binds to epidermal growth factor receptor and ErbB-4 and induces tryosine phosphorylation of epidermal growth factor receptor, ErbB-2, ErbB-3 and ErbB-4

T Komurasaki, H Toyoda, D Uchida, S Morimoto - Oncogene, 1997 - nature.com
Epiregulin is a member of the epidermal growth factor (EGF) family, and has certain
characteristics that are different from that of EGF, including mitogenic responses and binding …

Epiregulin expression by Ets-1 and ERK signaling pathway in Ki-ras-transformed cells

MC Cho, HS Choi, S Lee, BY Kim, M Jung… - Biochemical and …, 2008 - Elsevier
Epiregulin belongs to the epidermal growth factor family, binds to the epidermal growth
factor receptor, and its expression is upregulated in various cancer cells, but the regulatory …

Involvement of Deregulated Epiregulin Expression in Tumorigenesis in Vivo through Activated Ki-Ras Signaling Pathway in Human Colon Cancer Cells

I Baba, S Shirasawa, R Iwamoto, K Okumura… - Cancer research, 2000 - AACR
To identify the genes located downstream of the activated Ki-Ras signaling pathways in
human colon cancer cells, a PCR-based cDNA subtraction library was constructed between …

Epiregulin contributes to breast tumorigenesis through regulating matrix metalloproteinase 1 and promoting cell survival

M Farooqui, LR Bohrer, NJ Brady, P Chuntova… - Molecular cancer, 2015 - Springer
Background The epidermal growth factor (EGF) family of ligands has been implicated in
promoting breast cancer initiation, growth and progression. The contributions of EGF family …

Epiregulin: roles in normal physiology and cancer

DJ Riese II, RL Cullum - Seminars in cell & developmental biology, 2014 - Elsevier
Epiregulin is a 46-amino acid protein that belongs to the epidermal growth factor (EGF)
family of peptide hormones. Epiregulin binds to the EGF receptor (EGFR/ErbB1) and ErbB4 …

Epiregulin is not essential for development of intestinal tumors but is required for protection from intestinal damage

D Lee, RS Pearsall, S Das, SK Dey… - … and cellular biology, 2004 - Taylor & Francis
Epiregulin, an epidermal growth factor family member, acts as a local signal mediator and
shows dual biological activity, stimulating the proliferation of fibroblasts, hepatocytes …

Epiregulin as a marker for the initial steps of ovarian cancer development

A Amsterdam, E Shezen… - International …, 2011 - spandidos-publications.com
Epiregulin (Ep) was found to be produced in non-cancer ovarian cells in response to
gonadotropin stimulation as well in ovarian cancer cells in an autonomous manner …

Elevated epiregulin expression predicts poor prognosis in gastric cancer

Q Xia, Y Zhou, H Yong, X Wang, W Zhao, G Ding… - … -Research and Practice, 2019 - Elsevier
Epiregulin (EREG) is a novel family member of EGF-like ligands and have elevated
expression in a variety of human cancers. EREG expression promotes tumor progression …