Adenosine A2b receptors control A1 receptor‐mediated inhibition of synaptic transmission in the mouse hippocampus

FQ Gonçalves, J Pires, A Pliassova… - European Journal of …, 2015 - Wiley Online Library
Adenosine is a neuromodulator mostly acting through A1 (inhibitory) and A2A (excitatory)
receptors in the brain. A2B receptors (A2 BR) are Gs/q‐protein‐coupled receptors with low …

Adenosine A2A receptor facilitation of hippocampal synaptic transmission is dependent on tonic A1 receptor inhibition

LV Lopes, RA Cunha, B Kull, BB Fredholm, JA Ribeiro - Neuroscience, 2002 - Elsevier
Adenosine tonically inhibits synaptic transmission through actions at A1 receptors. It also
facilitates synaptic transmission, but it is unclear if this facilitation results from pre-and/or …

Adenosine A2A receptor facilitation of synaptic transmission in the CA1 area of the rat hippocampus requires protein kinase C but not protein kinase A activation

RA Cunha, JA Ribeiro - Neuroscience letters, 2000 - Elsevier
Adenosine is a neuromodulator in the hippocampus acting mainly via inhibitory A1 receptors
but also via facilitatory A2A receptors. We now investigated the transducing system operated …

Different synaptic and subsynaptic localization of adenosine A2A receptors in the hippocampus and striatum of the rat

N Rebola, PM Canas, CR Oliveira, RA Cunha - Neuroscience, 2005 - Elsevier
Adenosine A2A receptors are most abundant in the striatum where they control the
striatopallidal pathway thus controlling locomotion. Extra-striatal A2A receptors are …

Adenosine A2 receptors modulate hippocampal synaptic transmission via a cyclic-AMP-dependent pathway

K Kessey, DJ Mogul - Neuroscience, 1998 - Elsevier
Blockade of adenosine A2 receptors has been shown to significantly reduce the level of
tetanus-induced long-term potentiation in area CA1 of rat hippocampus [Kessey K. et …

Adenosine A1 and A2A receptors are co-expressed in pyramidal neurons and co-localized in glutamatergic nerve terminals of the rat hippocampus

N Rebola, RJ Rodrigues, LV Lopes, PJ Richardson… - Neuroscience, 2005 - Elsevier
Adenosine is a neuromodulator that controls neurotransmitter release through inhibitory A1
and facilitatory A2A receptors. Although both adenosine receptor-mediated inhibition and …

Activation of hippocampal adenosine A3 receptors produces a desensitization of A1 receptor-mediated responses in rat hippocampus

TV Dunwiddie, L Diao, HO Kim, JL Jiang… - Journal of …, 1997 - Soc Neuroscience
The adenosine A3 receptor is expressed in brain, but the consequences of activation of this
receptor on electrophysiological activity are unknown. We have characterized the actions of …

Adenosine A3 receptors in the rat hippocampus: Lack of interaction with A1 receptors

LV Lopes, N Rebola, AR Costenla… - Drug development …, 2003 - Wiley Online Library
Adenosine acts as a neuromodulator in the hippocampus essentially through activation of
inhibitory A1 receptors. Using single‐cell PCR analysis, we found that CA1 pyramidal cells …

Synaptic mechanisms of adenosine A2A receptor‐mediated hyperexcitability in the hippocampus

DM Rombo, K Newton, W Nissen, S Badurek… - …, 2015 - Wiley Online Library
Adenosine inhibits excitatory neurons widely in the brain through adenosine A1 receptor,
but activation of adenosine A2A receptor (A2AR) has an opposite effect promoting discharge …

Adenosine A3 receptors are located in neurons of the rat hippocampus

LV Lopes, N Rebola, PC Pinheiro, PJ Richardson… - …, 2003 - journals.lww.com
Adenosine is a neuromodulator acting mainly via inhibitory A 1 and facilitatory A 2A
receptors. Whole tissue PCR also identified adenosine A 3 receptors in the brain and A 3 …