Axon regeneration in the CNS is largely unsuccessful due to excess inhibitory extrinsic
factors within lesion sites together with an intrinsic inability of neurons to regrow following …

The C3-like ADP-ribosyltransferases exhibit a very confined substrate specificity compared
with other Rho-modifying bacterial toxins; they selectively modify the RhoA,-B, and-C …

Background. Peripheral axon regeneration is improved when the nerve lesion under
consideration has recently been preceded by another nerve injury. This is known as the …

The Rho signaling pathway regulates the cytoskeleton and motility and plays an important
role in neuronal growth inhibition. Here we demonstrate that inactivation of Rho or its …

Application of chondroitinase ABC (ChABC) to injured peripheral nerves improves axon
regeneration, but it is not known whether functional recovery is also improved. Recordings of …

Damage to neurons in the central nervous system often leads to a permanent loss of
function due to several factors, including reduced capacity of axons to regenerate and an …

Neurons in the adult mammalian CNS do not spontaneously regenerate axons after injury
due to CNS myelin and other inhibitory factors. Previous studies have showed that inhibition …

In rat dorsal root ganglia, histochemical staining of carbonic anhydrase (CA) and
cholinesterase (CE) yields a reciprocal pattern of activity: Sensory processes are CA positive …

Regeneration in the CNS is blocked by many different growth inhibitory proteins. To foster
regeneration, we have investigated a strategy to block the neuronal response to growth …

Despite the intrinsically greater capacity for axons to regenerate in injured peripheral nerves
than after injury to the central nervous system, functional recovery after most nerve injuries is …