Abstract Serotonin receptor type 3 (5-HT 3 receptor) is a ligand-gated ion channel that is
expressed in the central nervous system (CNS) as well as in the peripheral nervous system …

Chemotherapy-induced nausea and vomiting (CINV) remain the most common and
devastating side-effects associated with cancer chemotherapy. In recent decades, several …

In order to establish if the canine 5-hydroxytryptamine type 3A (5-HT3A) receptors share the
pharmacological profile with human 5-HT3A receptors, we cloned and performed a …

Abstract Serotonin (5‐hydroxytryptophan [5‐HT]) is a biologically active amine expressed in
platelets, in gastrointestinal (GI) cells and, to a lesser extent, in the central nervous system …

We report the cloning, molecular characterization, and pharmacological characterization of
the canine 5-HT2A and 5-HT2B receptors. The canine and human 5-HT2A receptors share …

Within the family of serotonin receptors, the 5-hydroxytryptamine-3 (5-HT3) receptor is the
only ligand-gated ion channel. It is composed of five subunits, of which the 5-HT3A and 5 …

The human 5-HT1E receptor gene was cloned more than a decade ago. Little is known
about its function, and there have been no reports of its existence in the genome of small …

Using membranes from stably or transiently transfected HEK293 cells cultured in 5‐HT‐free
medium and expressing the recombinant human 5‐HT7 receptor splice variants (h5‐HT7 …

Ferrets (Mustela putorius furo) are useful animals for determining anti-emetic activity via 5-
HT3 receptors in vivo. We isolated a cDNA encoding the 5-hydroxytryptamine (5-HT) type 3A …

Irritable bowel syndrome (IBS) is a chronic disease that causes abdominal pain and an
imbalance of defecation patterns due to gastrointestinal dysfunction. The cause of IBS …