Colony stimulating factors and myeloid cell biology in health and disease

JA Hamilton, A Achuthan - Trends in immunology, 2013 - cell.com
The colony stimulating factors (CSFs), granulocyte macrophage-CSF (GM-CSF),
macrophage-CSF (M-CSF or CSF-1) and granulocyte-CSF (G-CSF) were first identified as in …

Biological role of granulocyte macrophage colony-stimulating factor (GM-CSF) and macrophage colony-stimulating factor (M-CSF) on cells of the myeloid lineage

I Ushach, A Zlotnik - Journal of Leucocyte Biology, 2016 - academic.oup.com
Abstract M-CSF and GM-CSF are 2 important cytokines that regulate macrophage numbers
and function. Here, we review their known effects on cells of the macrophage-monocyte …

Colony-stimulating factors in inflammation and autoimmunity

JA Hamilton - Nature Reviews Immunology, 2008 - nature.com
Although they were originally defined as haematopoietic-cell growth factors, colony-
stimulating factors (CSFs) have been shown to have additional functions by acting directly …

Therapeutic applications of macrophage colony-stimulating factor-1 (CSF-1) and antagonists of CSF-1 receptor (CSF-1R) signaling

DA Hume, KPA MacDonald - … Journal of the American Society of …, 2012 - ashpublications.org
Macrophage-colony stimulating factor (CSF-1) signaling through its receptor (CSF-1R)
promotes the differentiation of myeloid progenitors into heterogeneous populations of …

Anti-colony-stimulating factor therapies for inflammatory and autoimmune diseases

JA Hamilton, AD Cook, PP Tak - Nature reviews Drug discovery, 2017 - nature.com
Granulocyte–macrophage colony-stimulating factor (GM-CSF), macrophage colony-
stimulating factor (M-CSF; also known as CSF1), granulocyte colony-stimulating factor (G …

GM-CSF: a promising target in inflammation and autoimmunity

KMC Lee, AA Achuthan, JA Hamilton - ImmunoTargets and therapy, 2020 - Taylor & Francis
The cytokine, granulocyte macrophage-colony stimulating factor (GM-CSF), was firstly
identified as being able to induce in vitro the proliferation and differentiation of bone marrow …

Targeting GM-CSF in inflammatory and autoimmune disorders

AA Achuthan, KMC Lee, JA Hamilton - Seminars in immunology, 2021 - Elsevier
Granulocyte macrophage-colony stimulating factor (GM-CSF) was originally identified as a
growth factor for its ability to promote the proliferation and differentiation in vitro of bone …

Colony-stimulating factor-1 in immunity and inflammation

V Chitu, ER Stanley - Current opinion in immunology, 2006 - Elsevier
Colony-stimulating factor-1 (CSF-1, also known as macrophage-CSF) is the primary
regulator of the survival, proliferation, differentiation and function of mononuclear …

An antibody against the colony-stimulating factor 1 receptor depletes the resident subset of monocytes and tissue-and tumor-associated macrophages but does not …

KPA MacDonald, JS Palmer, S Cronau… - Blood, The Journal …, 2010 - ashpublications.org
The development of the mononuclear phagocyte system requires macrophage colony-
stimulating factor (CSF-1) signaling through the CSF-1 receptor (CSF1R, CD115). We …

Granulocyte-macrophage colony-stimulating factor (CSF) and macrophage CSF-dependent macrophage phenotypes display differences in cytokine profiles and …

AJ Fleetwood, T Lawrence, JA Hamilton… - The Journal of …, 2007 - journals.aai.org
Abstract GM-CSF and M-CSF (CSF-1) can enhance macrophage lineage numbers as well
as modulate their differentiation and function. Of recent potential significance for the therapy …