Evidence for association and genetic linkage of the angiotensin-converting enzyme locus with hypertension and blood pressure in men but not women in the …

CJ O'Donnell, K Lindpaintner, MG Larson, VS Rao… - Circulation, 1998 - Am Heart Assoc
Background—There is controversy regarding the association of the angiotensin-converting
enzyme deletion-insertion (ACE D/I) polymorphism with systemic hypertension and with …

Deletion allele of angiotensin-converting enzyme gene increases risk of essential hypertension in Japanese men: the Suita Study

J Higaki, S Baba, T Katsuya, N Sato, K Ishikawa… - Circulation, 2000 - Am Heart Assoc
Background—The Framingham Study recently revealed that the homozygous deletion
polymorphism of the angiotensin-converting enzyme gene (ACE DD) is associated with …

Context-dependent associations of the ACE I/D polymorphism with blood pressure

ST Turner, E Boerwinkle, CF Sing - Hypertension, 1999 - Am Heart Assoc
The objective of the present study was to assess whether the influences of gender, age, or
measures of body size on blood pressure are homogeneous among genotypes of the …

A population study of ethnic variations in the angiotensin-converting enzyme I/D polymorphism: relationships with gender, hypertension and impaired glucose …

GA Sagnella, MJ Rothwell, AK Onipinla… - Journal of …, 1999 - journals.lww.com
Background The presence of the deletion allele of the angiotensin-converting enzyme (ACE)
I/D polymorphism is associated with an excess risk of vascular disease and diabetic …

Pharmacogenetic association of the angiotensin-converting enzyme insertion/deletion polymorphism on blood pressure and cardiovascular risk in relation to …

DK Arnett, BR Davis, CE Ford, E Boerwinkle… - Circulation, 2005 - Am Heart Assoc
Background—Previous studies have reported that blood pressure response to
antihypertensive medications is influenced by genetic variation in the renin-angiotensin …

Frequency of a deletion polymorphism in the gene for angiotensin converting enzyme is increased in African-Americans with hypertension

K Duru, S Farrow, JM Wang… - American journal of …, 1994 - academic.oup.com
In white populations, a deletion polymorphism in the gene for angiotensin converting
enzyme (ACE) appears to be associated with increased risk for myocardial infarction but not …

No association of Angiotensin-Converting enzyme 2 gene (ACE2) polymorphisms with essential hypertension

AV Benjafield, WYS Wang… - American journal of …, 2004 - academic.oup.com
Recent intriguing findings from genetic linkage, knockout, and physiologic studies in mice
and rats led us to conduct the first investigation of the novel angiotensin-converting enzyme …

Variation in the region of the angiotensin-converting enzyme gene influences interindividual differences in blood pressure levels in young white males

M Fornage, CI Amos, S Kardia, CF Sing, ST Turner… - Circulation, 1998 - Am Heart Assoc
Background—The renin-angiotensin system regulates blood pressure through its effects on
vascular tone, renal hemodynamics, and renal sodium and fluid balance. Methods and …

Association of a polymorphism of the angiotensin I-converting enzyme gene with essential hypertension

RYL Zee, Y Lou, LR Griffiths, BJ Morris - Biochemical and Biophysical …, 1992 - Elsevier
Angiotensin I-converting enzyme (ACE) is responsible for production of angiotensin II and
breakdown of kinins, leading to increased blood pressure (BP). Furthermore, ACE inhibitors …

Polymorphism of the angiotensin-converting enzyme gene and cardiovascular disease

H Schunkert - Journal of molecular medicine, 1997 - Springer
The angiotensin-converting enzyme (ACE) is an integral part of two enzymatic cascades,
one leading to the generation of angiotensin II and the other to the degradation of …