Molecular pathogenesis of multiple sclerosis

A Bar-Or, EML Oliveira, DE Anderson… - Journal of …, 1999 - Elsevier
Multiple sclerosis (MS) is best understood as an inflammatory disease of the central nervous
system (CNS) white matter characterized by demyelination, focal T cell and macrophage …

Cytokine signaling in multiple sclerosis: Lost in translation

K Göbel, T Ruck, SG Meuth - Multiple Sclerosis Journal, 2018 - journals.sagepub.com
Multiple sclerosis (MS) is a common neurological disorder of putative autoimmune origin.
Clinical studies delineate abnormal expression of specific cytokines over the course of …

Immunopathogenesis of multiple sclerosis

SM Agrawal, VW Yong - International review of neurobiology, 2007 - Elsevier
Multiple sclerosis (MS) is considered an immune‐mediated disorder in which immune cells
cross the blood–brain barrier to enter the central nervous system (CNS) wherein they …

Pathogenic mechanisms associated with different clinical courses of multiple sclerosis

H Lassmann - Frontiers in immunology, 2019 - frontiersin.org
In the majority of patients multiple sclerosis starts with a relapsing remitting course (RRMS),
which may at later times transform into secondary progressive disease (SPMS). In a minority …

[引用][C] Immunologic mechanisms and therapy in multiple sclerosis

DA HAFLER, HL WEINER - Immunological reviews, 1995 - Wiley Online Library
Multiple sclerosis (MS) is a chronic inflammatory disease of central nervous system (CNS)
myelin characterized by focal T-cell and macrophage infiltrates that lead to demyelination …

Cytokine networks in multiple sclerosis: lost in translation

L Codarri, A Fontana, B Becher - Current opinion in neurology, 2010 - journals.lww.com
Preclinical studies using the animal models for MS have yielded promising results, but
unfortunately the translation into the clinic is often disappointing. The reason for this may be …

Pathogenesis of multiple sclerosis

A Prat, J Antel - Current opinion in neurology, 2005 - journals.lww.com
Pathogenesis of multiple sclerosis : Current Opinion in Neurology Pathogenesis of multiple
sclerosis : Current Opinion in Neurology Log in or Register Subscribe to journalSubscribe Get new …

Multiple sclerosis immunology: the healthy immune system vs the MS immune system

LH Kasper, J Shoemaker - Neurology, 2010 - AAN Enterprises
Multiple sclerosis (MS) is a debilitating autoimmune disease characterized by both
inflammation and axonal degeneration. The resulting demyelination and subsequent …

Immunopathogenesis of multiple sclerosis

M Comabella, SJ Khoury - Clinical immunology, 2012 - Elsevier
Multiple sclerosis (MS) is a chronic disorder of the central nervous system characterized by
autoimmune inflammation, demyelination, and axonal damage. MS etiology remains …

Immune regulation of multiple sclerosis

HP Hartung, O Aktas, T Menge, BC Kieseier - Handbook of clinical …, 2014 - Elsevier
Multiple sclerosis (MS) is considered a prototype inflammatory autoimmune disorder of the
central nervous system (CNS). The etiology of this disease remains unknown, but an …