Anti-phospholipase A2 receptor antibody screening in nephrotic syndrome may identify a distinct subset of patients with primary membranous nephropathy

R Jurubiță, B Obrișcă, C Achim, G Micu… - … Urology and Nephrology, 2022 - Springer
Purpose We sought to investigate the utility of anti-PLA2R antibody as a non-invasive
screening method for the diagnosis of primary MN in patients with nephrotic syndrome (NS) …

Can use of the serum anti-PLA2R antibody negate the need for a renal biopsy in primary membranous nephropathy?

O Ragy, V Rautemaa, A Smith, P Brenchley… - PLoS …, 2023 - journals.plos.org
Background Since the emergence of the anti-PLA2R antibody (PLA2R-Ab) test, nephrology
practice has not changed dramatically, with most nephrologists still relying on a kidney …

Anti–Phospholipase A2 Receptor 1 and Anti–Cysteine Rich antibodies, domain recognition and rituximab efficacy in membranous nephropathy: a prospective cohort …

P Ruggenenti, L Reinhard, B Ruggiero, A Perna… - American Journal of …, 2024 - Elsevier
Rationale & Objective Proteinuria and anti–phospholipase A 2 receptor 1 (anti-PLA 2 R1)
antibody titers are associated with primary membranous nephropathy (MN) outcomes. We …

Pharmacological treatment of primary membranous nephropathy in 2016

AE van de Logt, JM Hofstra… - Expert review of clinical …, 2016 - Taylor & Francis
Introduction: Therapy in patients with primary membranous nephropathy is debated. The
discovery of anti-PLA2R antibodies provides opportunities for new treatment strategies …

Anti-phospholipase A2 Receptor Antibody and Immunosuppression in Membranous Nephropathy: More Evidence for Pathogenicity of Anti-phospholipase A: 2 …

PEC Brenchley - Journal of the American Society of Nephrology, 2015 - journals.lww.com
EDITORIALS www. jasn. org with primary membranous nephropathy (MN), 1 our
understanding of the role of anti-PLA2R in clinical disease has evolved rapidly. The initial …

Anti-PLA2R antibody levels and clinical risk factors for treatment nonresponse in membranous nephropathy

SJ Barbour, FC Fervenza, D Induruwage… - Clinical Journal of the …, 2023 - journals.lww.com
Background The 2021 Kidney Disease Improving Global Outcomes (KDIGO) guidelines
recommend following anti-phospholipase A2 receptor (PLA2R) antibody levels as a marker …

[HTML][HTML] Urine anti-PLA2R antibody is a novel biomarker of idiopathic membranous nephropathy

Y Wang, YX He, TT Diao, SY Wei, WR Qi, CC Wang… - Oncotarget, 2018 - ncbi.nlm.nih.gov
Since urine samples more directly reflect kidney alterations and damage than blood
samples, we investigated whether urine anti-PLA 2 R antibody (uPLA 2 R-Ab) could be …

Monthly mini-dose rituximab for primary anti-PLA2R-positive membranous nephropathy: a personalized approach

S Wang, Z Deng, Y Wang, W Bao, S Zhou, Z Cui… - BMC nephrology, 2023 - Springer
Background The currently recommended dose of rituximab for primary membranous
nephropathy is as high as that for lymphoma. However, the clinical manifestations of …

Epitope spreading of autoantibody response to PLA2R associates with poor prognosis in membranous nephropathy

B Seitz-Polski, G Dolla, C Payré… - Journal of the …, 2016 - journals.lww.com
The phospholipase A2 receptor (PLA2R1) is the major autoantigen in idiopathic
membranous nephropathy. However, the value of anti-PLA2R1 antibody titers in predicting …

Preliminary results of research on a new marker of idiopathic membranous nephropathy: anti-PLA2R

M Kozioł, A Sikora, M Kozioł-Montewka… - Polski merkuriusz …, 2014 - europepmc.org
Results Antibodies were detected in 12 patients (54.54%): diagnosed (n= 5) and monitor (n=
7). All of patients with exacerbated disease process in monitored group had positive test …