Abstract Interleukin-10 (IL-10) has a key role in regulating mucosal inflammation. The role of
functional polymorphisms at positions− 627 and− 1117 in the IL-10 gene as candidate …

Interleukin‐10 (IL‐10) is an anti‐inflammatory cytokine. Its production in humans is under
genetic control, and genotype defines high or low producers of this cytokine. This study …

Objective. Pathological evidence supports a potential role of the pro-and anti-inflammatory
cytokine network in the pathogenesis of inflammatory bowel disease (IBD). Moreover …

Background: Changes in cytokine expression have been frequently found in patients with
inflammatory bowel disease (IBD). Cytokine values outside the normal range may be …

Objective: To test whether IL-10 promoter region polymorphisms are associated with
susceptibility to inflammatory bowel disease, we examined the contribution of interleukin-10 …

The IL-6 gene maps to an area of chromosome 7 known to be significant for susceptibility to
inflammatory bowel disease. The functional effects of interleukin-6 (IL-6) polymorphisms in …

Although the importance of genetic susceptibility to IBD has been established by
epidemiological studies, the genes involved remain poorly characterized. Important …

Interleukin (IL)-20 belongs to the IL-10 family and is a potent immunomodulatory cytokine
with implications for pathogenesis in the inflammatory bowel disease (IBD). The interleukin …

The aim of this study was to assess the association of polymorphisms in the promoter region
of the IL-10 gene with the risk of inflammatory bowel disease (IBD), including Crohn's …

A Gly15Arg mutation in the interleukin-10 gene reduces secretion of interleukin-10 in
Crohnʼs disease Page 51 CHAPTER 3 A Gly15Arg mutation in the interleukin-10 gene …