An emerging area of investigation is the role of lipids as immunological antigens. CD1
glycoproteins comprise a family of molecules that are specialized for presenting lipids …

Specific T cell responses to a variety of self and microbial lipids depend on proper assembly
and intracellular trafficking of CD1 molecules that intersect with and load processed lipid …

CD1 proteins have been conserved throughout mammalian evolution and function to
present lipid antigens to T cells. Crystal structures of CD1‐lipid complexes show that CD1 …

A crucial feature of peptide antigen presentation by major histocompatibilty complex (MHC)
class I and II molecules is their differential ability to sample cytosolic and extracellular …

▪ Abstract This review summarizes the major features of CD1 genes and proteins, the
patterns of intracellular trafficking of CD1 molecules, and how they sample different …

Recently, different members of the CD1 family of MHC-like molecules have been shown to
sample different intracellular compartments to present lipid and glycolipid antigens to T cells …

T cells recognizing lipid antigens are present in large numbers in circulating blood. They
exert multiple functions including immunoregulation, tumour surveillance and protection …

Lipid presentation by CD1: the short and the long lipid story | Nature Immunology Skip to main
content Thank you for visiting nature.com. You are using a browser version with limited support …

Highlights•Human CD1 molecules present a diverse, overlapping repertoire of endogenous
lipids.•CD1 specific T cells comprise a significant percentage of blood αβ T cells.•Many CD1 …

CD1d is an MHC class I-like membrane glycoprotein that presents lipid Ags to NKT cells.
Despite intensive biochemical, genetic, and structural studies, the endogenous lipids …