Alzheimer's disease (AD) is a progressive neurodegenerative disorder associated with
memory and cognitive impairment. Donepezil is an acetylcholinesterase inhibitor used for …

Alzheimer's disease (AD) is a multifaceted and progressive neurodegenerative disease
characterized by accumulation of amyloid-beta (Aβ) and deficits of acetylcholine …

Alzheimer's disease (AD) is a progressive neurological disorder and is the most common
type of dementia. Amyloid β (Aβ) plaques play an important role in the pathophysiology of …

Pharmacological treatment of central nervous system (CNS) disorders is difficult, because
the blood–brain barrier (BBB) restricts the penetration of many drugs into the brain. To solve …

Objective: Alzheimer's disease (AD) is a progressive neurodegenerative disorder
manifested by cognitive, memory deterioration and variety of neuropsychiatric symptoms …

Introduction Donepezil (DPL), a specific acetylcholinesterase inhibitor, is used as a first-line
treatment to improve cognitive deficits in Alzheimer's disease (AD) and it might have a …

Donepezil (DPZ) is widely used in the treatment of Alzheimer's disease in tablet form for oral
administration. The pharmacological efficacy of this drug can be enhanced by the use of …

This study was aimed at preparing and characterizing solid lipid nanoparticles (SLNs) of
donepezil (DPL) for delivery to brain via nasal route. SLNs were prepared by solvent …

The oral administration of donepezil hydrochloride has low brain targeting efficiency
especially due to the presence of the blood–brain barrier leading to poor quality of …

The current research work aims to study the pharmacokinetic and nasal ciliotoxicity of
donepezil liposome–based in situ gel to treat Alzheimer's disease. The physicochemical …