Localized thrombin production appears to be a key event in the hemostatic response to the
vascular injury. This protein causes irreversible activation of platelets and is responsible for …

Thrombus growth at the site of vascular injury is mediated by the sequential events of
platelet recruitment, activation and aggregation concomitant with the initiation of the …

Current knowledge of the mechanisms of blood coagulation does not provide an answer to
one pivotal question: why is, in contrast to a pathological thrombus, the growth of normal …

Thrombin generation is the culminating event of the coagulation cascade. It is initiated after
the expression of tissue factor by endothelial cells and monocytes exposed to thrombogenic …

The objective of the review is to cover the formation of modern understanding of molecular
mechanisms of blood coagulation initiation. It was provided mainly by the research of …

Platelets play a key role in hemostasis as cofactors of thrombin generation, fibrin
polymerization centers, and initiators of clot retraction, while their ability to modulate clot …

Blood coagulation and fibrinolysis systems are enzymatic cascades in blood plasma that
control formation and dissolution of a fibrin clot, respectively. However, critical processes in …

Mural adhesion and aggregation of blood platelets are crucial for hemostasis but in
pathological situations can lead to myocardial infarction and stroke. The specific platelet …

The formation of a hemostatic thrombus is a key response of the hemostatic system to a wide
range of possible vascular damage. The main mechanism of thrombus growth in conditions …

Platelets actively participate in regulating thrombin production following physical or chemical
injury to blood vessels. Injury to blood vessels initiates activation of the large numbers of …