Breakdown of the epithelial barrier because of toxins or other insults leads to severe colitis.
Interleukin-10 (IL-10) is a critical regulator of this, yet its cellular targets and mechanisms of …

Inflammatory bowel disease encompasses a group of chronic-inflammatory conditions of the
colon and small intestine. These conditions are characterized by exacerbated inflammation …

IL-10 is an immunomodulatory cytokine that plays an obligate role in preventing
spontaneous enterocolitis in mice. However, little is known about IL-10 function in the …

IL‐10 is a regulatory cytokine that plays a major role in the homeostasis of the gut and this is
illustrated by the fact that IL‐10−/− mice develop spontaneous colitis. In this study, IL‐10 …

Summary Interleukin-10 (IL-10) is a pleiotropic anti-inflammatory cytokine produced and
sensed by most hematopoietic cells. Genome-wide association studies and experimental …

Summary Intact interleukin-10 receptor (IL-10R) signaling on effector and T regulatory (Treg)
cells are each independently required to maintain immune tolerance. Here we show that IL …

BACKGROUND &AIMS:: Progression from the acute to chronic phase of inflammatory bowel
disease cannot be easily evaluated in patients and has not been characterized in animal …

B cells mediate multiple functions that influence immune and inflammatory responses. In
mice, the addition of dextran sulfate sodium (DSS) to drinking water leads to immediate …

Background Regulatory cytokines are well known to modify experimental colitis in mice. The
aim of this study was to elucidate the effect of interleukin (IL)-10 derived from different …

Cytokines maintain intestinal health, but precise intercellular communication networks
remain poorly understood. Macrophages are immune sentinels of the intestinal tissue and …