Epigenetic alterations associated with war trauma and childhood maltreatment

L Ramo‐Fernández, A Schneider… - … sciences & the law, 2015 - Wiley Online Library
Survivors of war trauma or childhood maltreatment are at increased risk for trauma‐spectrum
disorders such as post‐traumatic stress disorder (PTSD). In addition, traumatic stress has …

Traumatic stress epigenetics

JR Pfeiffer, L Mutesa, M Uddin - Current behavioral neuroscience reports, 2018 - Springer
Abstract Purpose of Review Traumatic stress has profound impacts on many domains of life,
yet the mechanisms that confer risk for or resilience to the development of traumatic stress …

Epigenomic mechanisms of early adversity and HPA dysfunction: considerations for PTSD research

PO McGowan - Frontiers in psychiatry, 2013 - frontiersin.org
Childhood adversity can have life-long consequences for the response to stressful events
later in life. Abuse or severe neglect are well-known risk factors for post-traumatic stress …

Epigenetics in posttraumatic stress disorder

C Rampp, EB Binder, N Provençal - Progress in molecular biology and …, 2014 - Elsevier
Reported exposure to traumatic event is relatively common within the general population (40–
90%), but only a fraction of individuals will develop posttraumatic stress disorder (PTSD) …

Intergenerational trauma is associated with expression alterations in glucocorticoid-and immune-related genes

NP Daskalakis, C Xu, HN Bader… - …, 2021 - nature.com
Offspring of trauma survivors are more likely to develop PTSD, mood, and anxiety disorders
and demonstrate endocrine and molecular alterations compared to controls. This study …

Transgenerational epigenetic inheritance of traumatic experience in mammals

J Švorcová - Genes, 2023 - mdpi.com
In recent years, we have seen an increasing amount of evidence pointing to the existence of
a non-genetic heredity of the effects of events such as separation from parents, threat to life …

The neurobiological toll of child abuse and neglect

GN Neigh, CF Gillespie… - Trauma, Violence, & …, 2009 - journals.sagepub.com
Exposure to interpersonal violence or abuse affects the physical and emotional well-being of
affected individuals. In particular, exposure to trauma during development increases the risk …

Stress risk factors and stress-related pathology: neuroplasticity, epigenetics and endophenotypes

JJ Radley, M Kabbaj, L Jacobson, W Heydendael… - Stress, 2011 - Taylor & Francis
This paper highlights a symposium on stress risk factors and stress susceptibility, presented
at the Neurobiology of Stress workshop in Boulder, CO, in June 2010. This symposium …

Epigenetic mechanisms shape the biological response to trauma and risk for PTSD: a critical review

M Heinzelmann, J Gill - Nursing research and practice, 2013 - Wiley Online Library
Posttraumatic stress disorder (PTSD) develops in approximately one‐quarter of trauma‐
exposed individuals, leading us and others to question the mechanisms underlying this …

[PDF][PDF] The public reception of putative epigenetic mechanisms in the transgenerational effects of trauma

R Yehuda, A Lehrner, LM Bierer - Environmental epigenetics, 2018 - academic.oup.com
There has been great interest in the possibility that effects of trauma might be passed from
parent to offspring through epigenetic mechanisms. This topic has stimulated discussion and …