Genetic evidence of the regulatory role of parathyroid hormone–related protein in articular chondrocyte maintenance in an experimental mouse model

C Macica, G Liang, A Nasiri… - Arthritis & …, 2011 - Wiley Online Library
Objective Parathyroid hormone–related protein (PTHrP) regulates the rate of differentiation
of growth chondrocytes and is also expressed in articular chondrocytes. This study tested …

Parathyroid hormone‐related protein is abundant in osteoarthritic cartilage, and the parathyroid hormone‐related protein 1‐173 isoform is selectively induced by …

R Terkeltaub, M Lotz, K Johnson, D Deng… - Arthritis & …, 1998 - Wiley Online Library
Objective Parathyroid hormone‐related protein (PTHrP) is a major, locally expressed
regulator of growth cartilage chondrocyte proliferation, differentiation, synthetic function, and …

Regulation of articular chondrocyte proliferation and differentiation by Indian hedgehog and parathyroid hormone–related protein in mice

X Chen, CM Macica, A Nasiri… - Arthritis & Rheumatism …, 2008 - Wiley Online Library
Objective Chondrocytes of the epiphyseal growth zone are regulated by the Indian
hedgehog (IHH)–parathyroid hormone–related protein (PTHrP) axis. In weight‐bearing …

Inhibitory function of parathyroid hormone-related protein on chondrocyte hypertrophy: the implication for articular cartilage repair

W Zhang, J Chen, S Zhang, HW Ouyang - Arthritis research & therapy, 2012 - Springer
Cartilage repair tissue is usually accompanied by chondrocyte hypertrophy and osseous
overgrowths, and a role for parathyroid hormone-related protein (PTHrP) in inhibiting …

Sequential changes of parathyroid hormone related protein (PTHrP) in articular cartilage during progression of inflammatory and degenerative arthritis

E Gomez-Barrena, O Sanchez-Pernaute… - Annals of the …, 2004 - ard.bmj.com
Objective: To investigate immunolocalisation of parathyroid hormone related protein
(PTHrP) in two sequential models of experimental cartilage damage (inflammatory and …

Parathyroid Hormone–Related Protein Regulates Proliferation of Condylar Hypertrophic Chondrocytes

N Suda, S Shibata, K Yamazaki… - Journal of Bone and …, 1999 - academic.oup.com
The condylar cartilage, an important growth site in the mandible, shows characteristic modes
of growth and differentiation, eg, it shows delayed appearance in development relative to the …

Parathyroid hormone-related protein is induced by hypoxia and promotes expression of the differentiated phenotype of human articular chondrocytes

M Pelosi, S Lazzarano, BL Thoms, CL Murphy - Clinical science, 2013 - portlandpress.com
PTHrP (parathyroid hormone-related protein) is crucial for normal cartilage development
and long bone growth and acts to delay chondrocyte hypertrophy and terminal differentiation …

Human articular chondrocytes secrete parathyroid hormone–related protein and inhibit hypertrophy of mesenchymal stem cells in coculture during chondrogenesis

J Fischer, A Dickhut, M Rickert… - Arthritis & …, 2010 - Wiley Online Library
Objective The use of bone marrow–derived mesenchymal stem cells (MSCs) has shown
promise in cell‐based cartilage regeneration. A yet‐unsolved problem, however, is the …

Chondrocyte terminal differentiation, apoptosis, and type X collagen expression are downregulated by parathyroid hormone

EK Harrington, LE Lunsford… - The Anatomical Record …, 2004 - Wiley Online Library
Parathyroid hormone (PTH) regulates calcium and phosphate homeostasis through the
endocrine system. Parathyroid hormone‐related peptide (PTHrP) is a heterogeneous …

Parathyroid hormone/parathyroid hormone-related protein receptor signaling is required for maintenance of the growth plate in postnatal life

T Hirai, AS Chagin, T Kobayashi… - Proceedings of the …, 2011 - National Acad Sciences
Parathyroid hormone (PTH)-related protein (PTHrP), regulated by Indian hedgehog and
acting through the PTH/PTHrP receptor (PPR), is crucial for normal cartilage development …