Objective Osteoarthritis (OA) is polygenic with over 90 independent genome-wide
association loci so far reported. A key next step is the identification of target genes and the …

Osteoarthritis (OA) is a common, painful and debilitating disease of articulating joints
resulting from the age-associated loss of cartilage. Well-powered genetic studies have …

Osteoarthritis is a complex degenerative joint disease. Here, we investigate matched
genotype and methylation profiles of primary chondrocytes from macroscopically intact (low …

Osteoarthritis (OA) is a polygenic disease of older people resulting in the breakdown of
cartilage within articular joints. Although it is a leading cause of disability, there are no …

Objective To perform a genome‐wide DNA methylation study to identify DNA methylation
changes in osteoarthritic (OA) cartilage tissue. Methods The contribution of differentially …

Objective To perform a genome‐wide DNA methylation study to identify differential DNA
methylation patterns in subchondral bone underlying eroded and intact cartilage from …

Aim Osteoarthritis (OA) is caused by complex interactions between genetic and
environmental factors. Epigenetic mechanisms control the expression of genes and are …

Objective To identify methylation quantitative trait loci (mQTL s) correlating with osteoarthritis
(OA) risk alleles and to undertake mechanistic characterization as a means of target gene …

Epigenetic changes in articular chondrocytes are associated with osteoarthritis (OA) disease
progression. Numerous studies have identified differentially methylated cytosines in OA …

Background Evidence suggests that epigenetics plays a role in osteoarthrits (OA). The aim
of the study was to describethe genome wide DNA methylation changes in hip and knee OA …