Although the significance of BRD4 in the epigenetic memory and cancer genesis has been
intensively investigated, little is known about its function and potential roles during the …

Angiogenesis dysregulation contributes to inflammation, infections, immune disorders, and
carcinogenesis. Bromodomain-containing protein 4 (BRD4) is an epigenetic reader that …

Epigenetic mechanisms play an important role in the etiology of colorectal cancer (CRC)
and other malignancies due, in part, to deregulated bromodomain (BRD) functions …

Targeting epigenetic reader proteins by small molecule inhibitors represents a new
therapeutic concept in autoimmune diseases such as rheumatoid arthritis (RA). Although …

Oncogene-induced senescence is a p53-dependent defence mechanism against
uncontrolled proliferation. Consequently, many human tumours harbour p53 mutations and …

Oesophageal cancer is one of the most frequent solid malignancies and the leading cause
of cancer‐related death around the world. It is urgent to develop novel therapy strategies to …

Proline hydroxylation is a critical cellular mechanism regulating energy homeostasis and
development. Our previous study identified and validated Bromodomain-containing protein …

Bromodomain and extra-terminal domain (BET) proteins are epigenetic modulators that
regulate gene transcription through interacting with acetylated lysine residues of histone …

A variety of tumor-suppressor mechanisms exist to promote genome integrity and
organismal survival. One such mechanism is cellular senescence. In response to replicative …

Liver cancer is notoriously refractory to conventional therapeutics. Tumor progression is
governed by the interplay between tumor-promoting genes and tumor-suppressor genes …