Objective: To provide a rational basis for the dosage of fentanyl in newborn infants by
determining clearance in the first days of life. Study design: A continuous infusion of fentanyl …

Background Fentanyl is frequently used off-label in preterm newborns. Due to very limited
pharmacokinetic and pharmacodynamic data, fentanyl dosing is mostly based on …

Aim Fentanyl pharmacokinetics and pharmacodynamics are lacking in preterm infants. Our
aim was to study these and their relation with a new formulation of fentanyl 5 μg/mL for …

Although fentanyl administration by continuous infusion in newborns during ventilatory
support has increased, pharmacokinetic data are lacking. Our objective was to determine …

To determine whether the clearance of fentanyl in neonates varies with age, the authors
determined the pharmacokinetics of fentanyl in 14 humans ages 1-71 days and 15 lambs …

Abstract Background and Objective Fentanyl is an opioid commonly used to prevent and
treat severe pain in neonates; however, its use is off label and mostly based on bodyweight …

Fentanyl is a synthetic opioid that is very important in anesthetic practice because of its
relatively short time to peak analgesic effect and the rapid termination of action after small …

The pharmacokinetics of fentanyl were studied in fourteen neonates undergoing major
surgical procedures. Five patients were less than 1 day of age, seven ruere 1-4 days old …

To determine the effects of fentanyl in newborn and premature infants, we compared two
groups of 20 newborn and premature babies under artificial ventilation for severe respiratory …

The objective of this study was to determine hemodynamic effects and pharmacokinetic
profiles of fentanyl with continuous infusion in 1-to 3-day-old newborn piglets. The piglets …