Domains of P2X receptors involved in desensitization
P Werner, EP Seward, GN Buell… - Proceedings of the …, 1996 - National Acad Sciences
ATP-gated ion channels (P2X receptors) are abundantly expressed in both neuronal and
nonneuronal tissues, where they can serve as postsynaptic receptors. The response to ATP …
nonneuronal tissues, where they can serve as postsynaptic receptors. The response to ATP …
The role of positively charged amino acids in ATP recognition by human P2X1 receptors
S Ennion, S Hagan, RJ Evans - Journal of Biological Chemistry, 2000 - ASBMB
P2X receptors for ATP are a family of ligand-gated cation channels. There are 11 conserved
positive charges in the extracellular loop of P2X receptors. We have generated point …
positive charges in the extracellular loop of P2X receptors. We have generated point …
Cloning and tissue distribution of a novel P2X receptor from rat brain
F Soto, M Garcia-Guzman, C Karschin… - … and biophysical research …, 1996 - Elsevier
We have isolated the cDNA for a novel member (P2X6) of the ATP-gated ion channel family.
The rat P2X6nucleotide sequence encodes a 379 amino acid protein that conserves all the …
The rat P2X6nucleotide sequence encodes a 379 amino acid protein that conserves all the …
[HTML][HTML] Identification of amino acids within the P2X2 receptor C-terminus that regulate desensitization
FM Smith, PPA Humphrey… - The Journal of …, 1999 - ncbi.nlm.nih.gov
The ATP-activated P2X 2 (a) and P2X 2 (b) receptor splice variants, which differ only in their
C-terminal sequences, desensitize at different rates. We used mutational analysis to …
C-terminal sequences, desensitize at different rates. We used mutational analysis to …
Cloning of P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels
Two new P2X receptor cDNAs (P2X5 and P2X6) were isolated and expressed. All six
proteins are 36–48 percent identical and seem to have two transmembrane segments with a …
proteins are 36–48 percent identical and seem to have two transmembrane segments with a …
Single channel properties of ATP-gated cation channels (P2X receptors) heterologously expressed in Chinese hamster ovary cells
RJ Evans - Neuroscience letters, 1996 - Elsevier
The single channel properties of four P2X receptors heterologously expressed in Chinese
hamster ovary cells were determined from outside-out patch recordings. P2X1 and P2X4 …
hamster ovary cells were determined from outside-out patch recordings. P2X1 and P2X4 …
The intracellular amino terminus plays a dominant role in desensitization of ATP-gated P2X receptor ion channels
RC Allsopp, RJ Evans - Journal of Biological Chemistry, 2011 - ASBMB
P2X receptors show marked variations in the time-course of response to ATP application
from rapidly desensitizing P2X1 receptors to relatively sustained P2X2 receptors. In this …
from rapidly desensitizing P2X1 receptors to relatively sustained P2X2 receptors. In this …
ATP binding at human P2X1 receptors: contribution of aromatic and basic amino acids revealed using mutagenesis and partial agonists
JA Roberts, RJ Evans - Journal of Biological Chemistry, 2004 - ASBMB
P2X receptors comprise a family of ATP-gated ion channels with the basic amino acids Lys-
68, Arg-292, and Lys-309 (P2X 1 receptor numbering) contributing to agonist potency. In …
68, Arg-292, and Lys-309 (P2X 1 receptor numbering) contributing to agonist potency. In …
[HTML][HTML] Desensitization of the P2X2 receptor controlled by alternative splicing
U Brändle, P Spielmanns, R Osteroth, J Sim… - FEBS letters, 1997 - Elsevier
P2X receptors are ion channels gated by extracellular ATP. We report here cloning of a
P2X2 receptor splice variant (P2X2-2) carrying a 207 bp deletion in the intracellular C …
P2X2 receptor splice variant (P2X2-2) carrying a 207 bp deletion in the intracellular C …
A protein kinase C site highly conserved in P2X subunits controls the desensitization kinetics of P2X2 ATP-gated channels
P2X receptors are nonselective cation channels gated by extracellular ATP. Recombinant
mammalian P2X subunits assemble in homomeric ionotropic ATP receptors that differ by …
mammalian P2X subunits assemble in homomeric ionotropic ATP receptors that differ by …