Exposure to the thiolamine radioprotector N (2-mercaptoethyl)-1, 3-propanediamine (WR-
1065) induced apoptosis in the mouse TB8. 3 hybridoma after a 60-min (LD50= 4.5 mm) or …

Abstract N-(2-mercaptoethyl)-lt3-diaminopropane (WR1065) protects against radiation-
induced cell killing and mutagenesis at the hypoxanthine-guanine phosphoribosyl …

We compared the effects of the radioprotective aminothiols WR-1065 and WR-255591 on
the induction of DNA double-strand breaks (DSBs) and on the survival of aerated Chinese …

We have examined the radioprotective effect of WR-1065 on cultured Chinese hamster
ovary cells. The effects of the drug on the induction and rejoining of γ-ray-induced DNA …

The effect (s) of the radioprotector 2-[(aminopropyl) amino] ethanethiol (WR 1065) on fission-
neutron-induced DNA damage and repair in V79 Chinese hamster cells was determined by …

Considerable interest in understanding the role of DNA damage modification in
radioprotection by aminothiols was generated by the observation that cysteamine could …

The effect of two radioprotective agents (WR‐1065 and WR‐151326) was tested for their
ability to modify cell cycle progression. Each protector was administered at a concentration …

We compared the ability of three thiols–dithiothreitol (DTT), cysteamine and WR-151326–to
protect aerated Chinese hamster ovary cells from the lethal and DNA-damaging effects of γ …

The effects of the radioprotector 2-[(aminopropyl) amino] ethanethiol (WR-1065) on radiation-
induced cell killing and mutagenesis at the hypoxanthine-guanine phosphoribosyl …

Aminothiols such as WR-2721 and its active free thiol WR-1065 have previously been
shown to reduce mutations resulting from ionizing radiation in exponentially growing cells. In …