Annual influenza vaccination is an effective way to prevent human influenza. Current
vaccines are mainly focused on eliciting a strain-matched humoral immune response …

There is a diverse array of influenza viruses which circulate between different species,
reassort and drift over time. Current seasonal influenza vaccines are ineffective in controlling …

Protection against pathogens is mediated by both humoral responses (neutralizing
antibodies) and cellular immunity, both CD4+ and CD8+ cells. In the case of influenza …

Influenza is a major global health problem, causing infections of the respiratory tract, often
leading to acute pneumonia, life-threatening complications and even deaths. Over the last …

Influenza A virus is highly contagious, infecting 5–15% of the global population every year. It
causes significant morbidity and mortality, particularly among immunocompromised and at …

Next-generation vaccines that utilize T cells could potentially overcome the limitations of
current influenza vaccines that rely on antibodies to provide narrow subtype-specific …

Persistent and durable immunological memory forms the basis of any successful vaccination
protocol. Generation of pre-existing memory B cell and T cell pools is thus the key for …

Despite the widespread use of seasonal influenza vaccines, there is urgent need for a
universal influenza vaccine to provide broad, long-term protection. A number of factors …

Current flu vaccines rely on the induction of strain-specific neutralizing antibodies, which
leaves the population vulnerable to drifted seasonal or newly emerged pandemic strains …

Influenza A virus is a significant cause of morbidity and mortality worldwide, particularly
among young children and the elderly. Current vaccines induce neutralizing antibody …