Under hypercontractile conditions associated with increased intracellular calcium, male
hearts show enhanced ischemia/reperfusion injury compared to female hearts. Our aim in …

Sex differences in myocardial recovery have been reported after acute ischemia and
reperfusion injury. Estrogen and the estrogen receptor are critical determinants of …

BACKGROUND: Gender differences have been noted in acute ischemia/reperfusion injury.
Estrogen and the estrogen receptors (ER) appear to play a critical role in cardiovascular …

We investigated the function of estrogen receptor-α in global myocardial ischemia and
reperfusion injury in male estrogen receptor-α knockout (ERKO) and wild-type mice. Mouse …

Females have a lower incidence of heart failure and improved survival after myocardial
ischemia-reperfusion (I/R) compared with males. Although estrogen-suppressed …

Sex differences in responses to myocardial ischemia have been described, but whether
cardiomyocyte function is influenced by sex in the setting of ischemia and reperfusion has …

This study was designed to investigate whether treatment with an estrogen receptor-beta
(ER-β)-selective agonist (2, 3-bis (4-hydroxyphenyl)-propionitrile, DPN) can provide …

To test the hypothesis that estrogen confers cardioprotection by suppressing the expression
of β-adrenoceptor (β-AR), we first correlated the infarct size in response to ischemic insult …

Cardiovascular diseases are the major cause of morbidity and mortality in the developed
world, and are increasing in significance in the developing world. Elucidation of the …

Premenopausal women are much less prone to develop cardiovascular disease than men of
similar age, but this advantage no longer applies after menopause. We previously found that …