[HTML][HTML] Antibodies against low-density lipoprotein receptor–related protein 4 induce myasthenia gravis

C Shen, Y Lu, B Zhang, D Figueiredo… - The Journal of …, 2013 - Am Soc Clin Investig
Myasthenia gravis (MG) is the most common disorder affecting the neuromuscular junction
(NMJ). MG is frequently caused by autoantibodies against acetylcholine receptor (AChR) …

Autoantibodies to low‐density lipoprotein receptor–related protein 4 in myasthenia gravis

O Higuchi, J Hamuro, M Motomura… - Annals of …, 2011 - Wiley Online Library
Myasthenia gravis (MG) is an autoimmune disease of the neuromuscular junction, where
acetylcholine receptor (AChR), muscle‐specific kinase (MuSK), and low‐density lipoprotein …

Anti-LRP4 autoantibodies in AChR-and MuSK-antibody-negative myasthenia gravis

A Pevzner, B Schoser, K Peters, NC Cosma… - Journal of …, 2012 - Springer
Myasthenia gravis (MG) is an autoimmune disorder characterized by a defect in synaptic
transmission at the neuromuscular junction causing fluctuating muscle weakness with a …

Autoantibodies to lipoprotein-related protein 4 in patients with double-seronegative myasthenia gravis

B Zhang, JS Tzartos, M Belimezi, S Ragheb… - Archives of …, 2012 - jamanetwork.com
Objectives To determine whether patients with myasthenia gravis (MG) have serum
antibodies to lipoprotein-related protein 4 (LRP4), a newly identified receptor for agrin that is …

Induction of anti-agrin antibodies causes myasthenia gravis in mice

M Yan, Z Liu, E Fei, W Chen, X Lai, B Luo, P Chen… - Neuroscience, 2018 - Elsevier
Myasthenia gravis (MG) is an autoimmune disorder of the neuromuscular junction (NMJ).
Most cases of MG are caused by autoantibodies against the acetylcholine receptor (AChR) …

[HTML][HTML] Myasthenia gravis: pathogenic effects of autoantibodies on neuromuscular architecture

I Koneczny, R Herbst - Cells, 2019 - mdpi.com
Myasthenia gravis (MG) is an autoimmune disease of the neuromuscular junction (NMJ).
Autoantibodies target key molecules at the NMJ, such as the nicotinic acetylcholine receptor …

[HTML][HTML] MuSK myasthenia gravis IgG4 disrupts the interaction of LRP4 with MuSK but both IgG4 and IgG1-3 can disperse preformed agrin-independent AChR clusters

I Koneczny, J Cossins, P Waters, D Beeson, A Vincent - PloS one, 2013 - journals.plos.org
A variable proportion of patients with generalized myasthenia gravis (MG) have
autoantibodies to muscle specific tyrosine kinase (MuSK). During development agrin …

MuSK IgG4 autoantibodies cause myasthenia gravis by inhibiting binding between MuSK and Lrp4

MG Huijbers, W Zhang, R Klooster… - Proceedings of the …, 2013 - National Acad Sciences
Myasthenia gravis (MG) is a severely debilitating autoimmune disease that is due to a
decrease in the efficiency of synaptic transmission at neuromuscular synapses. MG is …

[HTML][HTML] Pathogenesis of myasthenia gravis: update on disease types, models, and mechanisms

WD Phillips, A Vincent - F1000Research, 2016 - ncbi.nlm.nih.gov
Myasthenia gravis is an autoimmune disease of the neuromuscular junction (NMJ) caused
by antibodies that attack components of the postsynaptic membrane, impair neuromuscular …

[HTML][HTML] Myasthenia gravis with antibodies against muscle specific kinase: an update on clinical features, pathophysiology and treatment

M Cao, I Koneczny, A Vincent - Frontiers in Molecular Neuroscience, 2020 - frontiersin.org
Muscle Specific Kinase myasthenia gravis (MuSK-MG) is an autoimmune disease that
impairs neuromuscular transmission leading to generalized muscle weakness. Compared to …