Cardiovascular outcome trials in obesity: a review

JPH Wilding, S Jacob - Obesity reviews, 2021 - Wiley Online Library
Obesity is a global epidemic associated with over 200 health complications and a significant
risk of developing cardiovascular disease (CVD), partly by increasing classical risk factors …

The risk of cardiovascular complications with current obesity drugs

AM Chao, TA Wadden, RI Berkowitz… - Expert opinion on …, 2020 - Taylor & Francis
Introduction Obesity is associated with an increased risk of cardiovascular morbidity and
mortality. Four medications are approved by the US Food and Drug Administration (FDA) for …

Cardiovascular effects of the new weight loss agents

MH Vorsanger, P Subramanyam, HS Weintraub… - Journal of the American …, 2016 - jacc.org
The global obesity epidemic and its impact on cardiovascular outcomes is a topic of ongoing
debate and investigation in the cardiology community. It is well known that obesity is …

LEADER 5: prevalence and cardiometabolic impact of obesity in cardiovascular high-risk patients with type 2 diabetes mellitus: baseline global data from the LEADER …

L Masmiquel, LA Leiter, J Vidal, S Bain, J Petrie… - Cardiovascular …, 2016 - Springer
Background Epidemiological data on obesity are needed, particularly in patients with type 2
diabetes mellitus (T2DM) and high cardiovascular (CV) risk. We used the baseline data of …

Clinical outcomes associated with drugs for obesity and overweight: A systematic review and network meta‐analysis of randomized controlled trials

A Iannone, P Natale, SC Palmer… - Diabetes, Obesity …, 2023 - Wiley Online Library
Aim To compare the benefits and harms of drugs approved for weight management in adults
with obesity or overweight. Materials and Methods We performed a systematic review of …

[HTML][HTML] Semaglutide effects on cardiovascular outcomes in people with overweight or obesity (SELECT) rationale and design

DH Ryan, I Lingvay, HM Colhoun, J Deanfield… - American heart …, 2020 - Elsevier
Cardiovascular disease (CVD) is a major cause of morbidity and mortality. Although it has
been widely appreciated that obesity is a major risk factor for CVD, treatments that produce …

Benefit-risk assessment of obesity drugs: focus on glucagon-like peptide-1 receptor agonists

RM Christensen, CR Juhl, SS Torekov - Drug safety, 2019 - Springer
The prevalence of obesity and related comorbidities is increasing worldwide. Furthermore,
clinically meaningful body weight losses has proven difficult to achieve and especially to …

Pharmacotherapy for obesity: recent evolution and implications for cardiovascular risk reduction

KC Maki, CF Kirkpatrick, DB Allison… - Expert Review of …, 2023 - Taylor & Francis
Introduction Obesity is highly prevalent in the US and is associated with an increased risk of
major adverse cardiovascular events (MACE). Modalities for the management of obesity …

Obesity, cardiovascular disease, and the promising role of semaglutide: insights from the SELECT trial

H Irfan - Current Problems in Cardiology, 2023 - Elsevier
Cardiovascular disease (CVD) is a leading global cause of death, with preventable risk
factors like obesity contributing most to it. Obesity's association with CVD originate from …

[HTML][HTML] A review of the evidence on cardiovascular outcomes from obesity treatment

RA Wahab, CW le Roux - Obesity Pillars, 2023 - Elsevier
Background Obesity is a chronic disease with a myriad of complications including
cardiovascular disease. There is a growing interest to examine if obesity treatment is …