MYC represents a transcription factor with oncogenic potential converting multiple cellular
signals into a broad transcriptional response, thereby controlling the expression of …

The transcription factor proto-oncogene c-MYC (hereafter MYC) was first identified more
than 3 decades ago and has since been found deregulated in a wide variety of the most …

The MYC oncoprotein functions as a master regulator of cellular transcription and executes
non-transcriptional tasks relevant to DNA replication and cell cycle regulation, thereby …

The activated product of the myc oncogene deregulates both cell growth and death check
points and, in a permissive environment, rapidly accelerates the affected clone through the …

Activation of the MYC oncoprotein is among the most ubiquitous events in human cancer.
MYC functions in part as a sequence-specific regulator of transcription. Although early …

Abstract MYC proteins (c-MYC, MYCN, and MYCL) regulate processes involved in many if
not all aspects of cell fate. Therefore, it is not surprising that the MYC genes are deregulated …

MYC regulates a complex biological program by transcriptionally activating and repressing
its numerous target genes. As such, MYC is a master regulator of many processes, including …

MYC is a proto-oncogene regulating a large number of genes involved in a plethora of
cellular functions. Its deregulation results in activation of MYC gene expression and/or an …

MYC is a master transcriptional regulator that controls almost all cellular processes. Over the
last several decades, researchers have strived to define the context-dependent …

MYC overexpression has been implicated in the pathogenesis of most types of human
cancers. MYC is likely to contribute to tumorigenesis by its effects on global gene …