The quest for targets executing MYC-dependent cell transformation
M Hartl - Frontiers in oncology, 2016 - frontiersin.org
MYC represents a transcription factor with oncogenic potential converting multiple cellular
signals into a broad transcriptional response, thereby controlling the expression of …
signals into a broad transcriptional response, thereby controlling the expression of …
Taking on challenging targets: making MYC druggable
D Horiuchi, B Anderton, A Goga - American Society of Clinical …, 2014 - ascopubs.org
The transcription factor proto-oncogene c-MYC (hereafter MYC) was first identified more
than 3 decades ago and has since been found deregulated in a wide variety of the most …
than 3 decades ago and has since been found deregulated in a wide variety of the most …
Strategies to target the cancer driver MYC in tumor cells
LI Weber, M Hartl - Frontiers in Oncology, 2023 - frontiersin.org
The MYC oncoprotein functions as a master regulator of cellular transcription and executes
non-transcriptional tasks relevant to DNA replication and cell cycle regulation, thereby …
non-transcriptional tasks relevant to DNA replication and cell cycle regulation, thereby …
The myc oncogene: MarvelouslY complex
SK Oster, CSW Ho, EL Soucie, LZ Penn - 2002 - Elsevier
The activated product of the myc oncogene deregulates both cell growth and death check
points and, in a permissive environment, rapidly accelerates the affected clone through the …
points and, in a permissive environment, rapidly accelerates the affected clone through the …
Emerging concepts in the analysis of transcriptional targets of the MYC oncoprotein: are the targets targetable?
SB McMahon - Genes & cancer, 2010 - journals.sagepub.com
Activation of the MYC oncoprotein is among the most ubiquitous events in human cancer.
MYC functions in part as a sequence-specific regulator of transcription. Although early …
MYC functions in part as a sequence-specific regulator of transcription. Although early …
MYC in oncogenesis and as a target for cancer therapies
A Albihn, JI Johnsen, MA Henriksson - Advances in cancer research, 2010 - Elsevier
Abstract MYC proteins (c-MYC, MYCN, and MYCL) regulate processes involved in many if
not all aspects of cell fate. Therefore, it is not surprising that the MYC genes are deregulated …
not all aspects of cell fate. Therefore, it is not surprising that the MYC genes are deregulated …
MYC deregulation in primary human cancers
MYC regulates a complex biological program by transcriptionally activating and repressing
its numerous target genes. As such, MYC is a master regulator of many processes, including …
its numerous target genes. As such, MYC is a master regulator of many processes, including …
Gene transactivation and transrepression in myc-driven cancers
M Scafuro, L Capasso, V Carafa, L Altucci… - International journal of …, 2021 - mdpi.com
MYC is a proto-oncogene regulating a large number of genes involved in a plethora of
cellular functions. Its deregulation results in activation of MYC gene expression and/or an …
cellular functions. Its deregulation results in activation of MYC gene expression and/or an …
Mission possible: advances in MYC therapeutic targeting in cancer
BL Allen-Petersen, RC Sears - BioDrugs, 2019 - Springer
MYC is a master transcriptional regulator that controls almost all cellular processes. Over the
last several decades, researchers have strived to define the context-dependent …
last several decades, researchers have strived to define the context-dependent …
Genomic and proteomic analysis reveals a threshold level of MYC required for tumor maintenance
MYC overexpression has been implicated in the pathogenesis of most types of human
cancers. MYC is likely to contribute to tumorigenesis by its effects on global gene …
cancers. MYC is likely to contribute to tumorigenesis by its effects on global gene …