Atmospheric particulate matter impairs cognition by modulating synaptic function via the nose-to-brain route

C Liang, Y Jiang, T Zhang, Y Ji, Y Zhang, Y Sun… - Science of The Total …, 2023 - Elsevier
Atmospheric particulate matter (PM), a ubiquitous air pollutant, is the leading environmental
risk factor for mortality worldwide. Experimental and epidemiological studies consistently …

Ambient PM2. 5 chronic exposure leads to cognitive decline in mice: From pulmonary to neuronal inflammation

Y Shou, X Zhu, D Zhu, H Yin, Y Shi, M Chen, L Lu… - Toxicology letters, 2020 - Elsevier
Abstract Fine particulate matter 2.5 (PM 2.5), one of the main components of air pollutants,
seriously threatens human health. Possible neuronal dysfunction induced by PM 2.5 has …

Exposure to PM2. 5 induces neurotoxicity, mitochondrial dysfunction, oxidative stress and inflammation in human SH-SY5Y neuronal cells

CH Lin, CJB Nicol, C Wan, SJ Chen, RN Huang… - Neurotoxicology, 2022 - Elsevier
Ambient air pollution is a global public health issue. Recent evidence suggests that
exposure to fine aerosolized particulate matter (PM) as small as≤ 2.5 microns (PM 2.5) is …

A review of respirable fine particulate matter (PM2.5)-induced brain damage

W Li, G Lin, Z Xiao, Y Zhang, B Li, Y Zhou… - Frontiers in Molecular …, 2022 - frontiersin.org
Respirable fine particulate matter (PM2. 5) has been one of the most widely publicized
indicators of pollution in recent years. Epidemiological studies have established a strong …

An air particulate pollutant induces neuroinflammation and neurodegeneration in human brain models

YJ Kang, HY Tan, CY Lee, H Cho - Advanced Science, 2021 - Wiley Online Library
Abstract Fine particulate matter (PM2. 5), a major component among air pollutants,
highlights as a global health concern. Several epidemiological studies show the correlation …

Neurodevelopmental toxicity induced by PM2. 5 Exposure and its possible role in Neurodegenerative and mental disorders

X Liu, J Huang, C Song, T Zhang… - Human & …, 2023 - journals.sagepub.com
Recent extensive evidence suggests that ambient fine particulate matter (PM2. 5, with an
aerodynamic diameter≤ 2.5 μm) may be neurotoxic to the brain and cause central nervous …

PM2. 5 impairs neurobehavior by oxidative stress and myelin sheaths injury of brain in the rat

Q Zhang, Q Li, J Ma, Y Zhao - Environmental Pollution, 2018 - Elsevier
Air particulate matter (PM) is a serious environmental problem that has been found to cause
neuropathological disorders. Although the general toxicity of PM2. 5 has been intensively …

Neurotoxicity of the air-borne particles: from molecular events to human diseases

F Liu, C Liu, Y Liu, J Wang, Y Wang, B Yan - Journal of Hazardous Materials, 2023 - Elsevier
Exposure to PM 2.5 is associated with an increased incidence of CNS diseases in humans,
as confirmed by numerous epidemiological studies. Animal models have demonstrated that …

Air pollution impairs cognition, provokes depressive-like behaviors and alters hippocampal cytokine expression and morphology

LK Fonken, X Xu, ZM Weil, G Chen, Q Sun… - Molecular …, 2011 - nature.com
Particulate matter air pollution is a pervasive global risk factor implicated in the genesis of
pulmonary and cardiovascular disease. Although the effects of prolonged exposure to air …

Three month inhalation exposure to low-level PM2.5 induced brain toxicity in an Alzheimer's disease mouse model

SH Lee, YH Chen, CC Chien, YH Yan, HC Chen… - PLoS …, 2021 - journals.plos.org
Although numerous epidemiological studies revealed an association between ambient fine
particulate matter (PM2. 5) exposure and Alzheimer's disease (AD), the PM2. 5-induced …