Cycling Lgr5+ stem cells fuel the rapid turnover of the adult intestinal epithelium. The
existence of quiescent Lgr5+ cells has been reported, while an alternative quiescent stem …

Lifelong self-renewal of the adult intestinal epithelium requires the activity of stem cells
located in mucosal crypts. Lgr5 and Bmi1 are two molecular markers of crypt-cell …

Lgr5+ crypt base columnar cells, the operational intestinal stem cells (ISCs), are thought to
be dispensable for small intestinal (SI) homeostasis. Using a Lgr5-2A-DTR (diphtheria toxin …

During late mitosis and the early G1 phase, the origins of replication are licensed by binding
to double hexamers of MCM2–7. In this study, we investigated how licensing and …

Background & Aims In the mouse intestinal epithelium, Lgr5+ stem cells are vulnerable to
injury, owing to their predominantly cycling nature, and their progenies de-differentiate to …

Two types of stem cells are currently defined in small intestinal crypts: cycling crypt base
columnar (CBC) cells and quiescent '+ 4'cells. Here, we combine transcriptomics with …

Intestinal stem cells, characterized by high Lgr5 expression, reside between Paneth cells at
the small intestinal crypt base and divide every day. We have carried out fate mapping of …

Since the discovery of LGR5 as a marker of intestinal stem cells, the field has developed
explosively and led to many new avenues of research. The inner workings of the intestinal …

During homeostasis, the colonic epithelium is replenished every 3–5 days by rapidly cycling
Lgr5+ stem cells. However, various insults can lead to depletion of Lgr5+ stem cells, and …

Lgr5+ adult intestinal stem cells are highly proliferative throughout life. Single Lgr5+ stem
cells can be cultured into three-dimensional organoids containing all intestinal epithelial cell …