Organizing membrane-curving proteins: the emerging dynamical picture
Highlights•Membrane reshaping in the cell, such as during trafficking, endocytosis, division
and other phenomena, is highly dynamic and typically involves a multitude of components …
and other phenomena, is highly dynamic and typically involves a multitude of components …
A review of mechanics-based mesoscopic membrane remodeling methods: capturing both the physics and the chemical diversity
G Kumar, SC Duggisetty, A Srivastava - The Journal of Membrane Biology, 2022 - Springer
Specialized classes of proteins, working together in a tightly orchestrated manner, induce
and maintain highly curved cellular and organelles membrane morphology. Due to the …
and maintain highly curved cellular and organelles membrane morphology. Due to the …
Making the cut: Multiscale simulation of membrane remodeling
J Beiter, GA Voth - Current Opinion in Structural Biology, 2024 - Elsevier
Biological membranes are dynamic heterogeneous materials, and their shape and
organization are tightly coupled to the properties of the proteins in and around them …
organization are tightly coupled to the properties of the proteins in and around them …
Thermodynamics and kinetics of aggregation of flexible peripheral membrane proteins
Biomembrane remodeling is essential for cellular trafficking, with membrane-binding
peripheral proteins playing a key role in it. Significant membrane remodeling as in endo-and …
peripheral proteins playing a key role in it. Significant membrane remodeling as in endo-and …
Mesoscale computational studies of membrane bilayer remodeling by curvature-inducing proteins
Biological membranes constitute boundaries of cells and cell organelles. These membranes
are soft fluid interfaces whose thermodynamic states are dictated by bending moduli …
are soft fluid interfaces whose thermodynamic states are dictated by bending moduli …
Membrane remodeling by surface-bound protein aggregates: insights from coarse-grained molecular dynamics simulation
H Li, AA Gorfe - The Journal of Physical Chemistry Letters, 2014 - ACS Publications
The mechanism of curvature generation in membranes has been studied for decades due to
its important role in many cellular functions. However, it is not clear if, or how, aggregates of …
its important role in many cellular functions. However, it is not clear if, or how, aggregates of …
Multiscale simulation of protein mediated membrane remodeling
Proteins interacting with membranes can result in substantial membrane deformations and
curvatures. This effect is known in its broadest terms as membrane remodeling. This review …
curvatures. This effect is known in its broadest terms as membrane remodeling. This review …
Aggregation of model membrane proteins, modulated by hydrophobic mismatch, membrane curvature, and protein class
DL Parton, JW Klingelhoefer, MSP Sansom - Biophysical journal, 2011 - cell.com
Aggregation of transmembrane proteins is important for many biological processes, such as
protein sorting and cell signaling, and also for in vitro processes such as two-dimensional …
protein sorting and cell signaling, and also for in vitro processes such as two-dimensional …
Modeling membrane reshaping driven by dynamic protein assemblies
Y Fu, ME Johnson - Current opinion in structural biology, 2023 - Elsevier
Remodeling of membranes in living systems is almost universally coupled to self-assembly
of soluble proteins. Proteins assemble into semi-rigid shells that reshape attached …
of soluble proteins. Proteins assemble into semi-rigid shells that reshape attached …
Membrane compartmentalization reducing the mobility of lipids and proteins within a model plasma membrane
The cytoskeleton underlying cell membranes may influence the dynamic organization of
proteins and lipids within the bilayer by immobilizing certain transmembrane (TM) proteins …
proteins and lipids within the bilayer by immobilizing certain transmembrane (TM) proteins …