Biochemical differences and similarities between the DEAD-Box helicase orthologs DDX3X and Ded1p
DDX3X is a conserved DEAD-box RNA helicase involved in translation initiation and other
processes of RNA metabolism. Mutations in human DDX3X and deregulation of its …
processes of RNA metabolism. Mutations in human DDX3X and deregulation of its …
lncRNA SLERT controls phase separation of FC/DFCs to facilitate Pol I transcription
RNA polymerase I (Pol I) transcription takes place at the border of the fibrillar center (FC)
and the dense fibrillar component (DFC) in the nucleolus. Here, we report that individual …
and the dense fibrillar component (DFC) in the nucleolus. Here, we report that individual …
[HTML][HTML] DDX3X regulates cell survival and cell cycle during mouse early embryonic development
Q Li, P Zhang, C Zhang, Y Wang, R Wan… - Journal of biomedical …, 2014 - ncbi.nlm.nih.gov
DDX3X is a highly conserved DEAD-box RNA helicase that participates in RNA
transcription, RNA splicing, and mRNA transport, translation, and nucleo-cytoplasmic …
transcription, RNA splicing, and mRNA transport, translation, and nucleo-cytoplasmic …
Multivalent m6A motifs promote phase separation of YTHDF proteins
Dear Editor, Posttranscriptional modifications of coding and non-coding RNAs are prevalent
in cells. N6-methyladenosine (m6A) is the most abundant type of modification on eukaryotic …
in cells. N6-methyladenosine (m6A) is the most abundant type of modification on eukaryotic …
RNA helicase DDX21 coordinates transcription and ribosomal RNA processing
DEAD-box RNA helicases are vital for the regulation of various aspects of the RNA life cycle,
but the molecular underpinnings of their involvement, particularly in mammalian cells …
but the molecular underpinnings of their involvement, particularly in mammalian cells …
It's not just a phase: function and characteristics of RNA-binding proteins in phase separation
HJ Wiedner, J Giudice - Nature structural & molecular biology, 2021 - nature.com
Biomolecular condensates that form via phase separation are increasingly regarded as
coordinators of cellular reactions that regulate a wide variety of biological phenomena …
coordinators of cellular reactions that regulate a wide variety of biological phenomena …
A long noncoding RNA regulates sister chromatid cohesion
Long noncoding RNAs (lncRNAs) are involved in diverse cellular processes through
multiple mechanisms. Here, we describe a previously uncharacterized human lncRNA …
multiple mechanisms. Here, we describe a previously uncharacterized human lncRNA …
Human DDX3Y, the Y-encoded isoform of RNA helicase DDX3, rescues a hamster temperature-sensitive ET24 mutant cell line with a DDX3X mutation
T Sekiguchi, H Iida, J Fukumura, T Nishimoto - Experimental cell research, 2004 - Elsevier
We investigated the function of DDX3Y, the Y chromosome AZFa region encoding a putative
DEAD-box RNA helicase protein, the loss of which results in oligozoospermia or …
DEAD-box RNA helicase protein, the loss of which results in oligozoospermia or …
DHX9 helicase promotes R-loop formation in cells with impaired RNA splicing
P Chakraborty, JTJ Huang, K Hiom - Nature communications, 2018 - nature.com
R-loops are stable nucleic acid structures that have important physiological functions, but
which also pose a significant threat to genomic stability. Increased R-loops cause replication …
which also pose a significant threat to genomic stability. Increased R-loops cause replication …
The RNA helicase DHX 9 establishes nucleolar heterochromatin, and this activity is required for embryonic stem cell differentiation
Long non‐coding RNA s (lnc RNA s) have been implicated in the regulation of chromatin
conformation and epigenetic patterns. lnc RNA expression levels are widely taken as an …
conformation and epigenetic patterns. lnc RNA expression levels are widely taken as an …