Liquid–liquid phase separation (LLPS) is thought to contribute to the establishment of many
biomolecular condensates, eukaryotic cell structures that concentrate diverse …

Chromatin modification and higher-order chromosome structure play key roles in gene
regulation, but their functional interplay in controlling gene expression is elusive. We have …

DExD (DDX)-and DExH (DHX)-box RNA helicases, named after their Asp-Glu-x-Asp/His
motifs, are integral to almost all RNA metabolic processes in eukaryotic cells. They play …

Members of the DExH/D superfamily of nucleic acid–activated nucleotide triphosphatases
are essential for virtually all aspects of RNA metabolism, including pre–messenger RNA …

Cytosine methylation regulates essential genome functions across eukaryotes, but the
fundamental question of whether nucleosomal or naked DNA is the preferred substrate of …

Little is known about the functional domain architecture of long noncoding RNAs (lncRNAs)
because of a relative paucity of suitable methods to analyze RNA function at a domain level …

DEXD/H-box RNA helicases couple ATP hydrolysis to RNA remodeling by an unknown
mechanism. We used x-ray crystallography and biochemical analysis of the human DEXD/H …

Background Understanding animal development and physiology at a molecular-biological
level has been advanced by the ability to determine at high resolution the repertoire of …

Summary Asp‐Glu‐Ala‐Asp (DEAD)‐box polypeptide 3, or DDX3, belongs to the DEAD‐box
family of ATP‐dependent RNA helicases and is known to play different roles in RNA …

Dysregulated rRNA synthesis by RNA polymerase I (Pol I) is associated with uncontrolled
cell proliferation. Here, we report a box H/ACA small nucleolar RNA (snoRNA)-ended long …