A precise understanding in the functional competence of mammalian sperm is essential to
generate clinical advances for the treatment of infertility and novel contraceptive strategies …

New Methods for the Diagnosis of Defective Human Sperm Function and Implications for
Treatment Page 1 Chapter 4 New Methods for the Diagnosis of Defective Human Sperm …

Different steps of sperm activation such as acrosomal reaction and capacitation are
described in details. The molecules involved in sperm-egg interaction are also reported.

Fertilization is a stepwise process that allows two mature gametes to reach each other, fuse
and eventually give rise to a new individual. Despite the tremendous importance of …

Recent evidence suggests that among patients attending infertility clinics for the first time,
approximately 1 in 4 is characterised by a clear-cut defect in the functional competence of …

With increasing medical utilization of assisted reproductive technology (ART), scientists and
clinicians have been able to study extensively multiple cell functions operating …

This review considers the role of the sperm in fertilization, addressing areas of
misunderstanding and unfounded assumptions and taking particular advantage of the large …

Our understanding of the causes of male infertility and our ability to develop an appropriate
range of diagnostic tests are both dependent upon a knowledge of the cellular mechanisms …

1Biostatistics and Bioinformatics Unit & Department of Medical Biochemistry and
Immunology, School of Medicine, Cardiff University, Cardiff, UK, 2Academic Unit of …

The present era of infertility management is characterized by an increasing interest in
defects of sperm-egg interactions. When the spermatozoon meets the egg, it must first react …