The prefrontal cortex (PFC) regulates a wide range of sensory experiences. Chronic pain is
known to impair normal neural response, leading to enhanced aversion. However, it …

Acute pain evokes protective neural and behavioral responses. Chronic pain, however,
disrupts normal nociceptive processing. The prefrontal cortex (PFC) is known to exert top …

The brain integrates information about the intensity, quality, and location of noxious inputs
with other states such as attention, anxiety, fear, and expectation. A key brain region where …

Neural circuits that determine the perception and modulation of pain remain poorly
understood. The prefrontal cortex (PFC) provides top-down control of sensory and affective …

The medial prefrontal cortex (mPFC) plays a major role in both sensory and affective aspects
of pain. There is extensive evidence that chronic pain produces functional changes within …

Pain chronicity involves unpleasant experience in both somatosensory and affective
aspects, accompanied with the prefrontal cortex (PFC) neuroplastic alterations. However …

Neurons in the prefrontal cortex (PFC) can provide top-down regulation of sensory-affective
experiences such as pain. Bottom-up modulation of sensory coding in the PFC, however …

Pain involves an intrinsically dynamic connectome characterized by fluctuating spontaneous
brain activity and continuous neuroplastic changes of relevant circuits. Activity in the …

Cortical mechanisms that regulate acute or chronic pain remain poorly understood. The
prefrontal cortex (PFC) exerts crucial control of sensory and affective behaviors. Recent …

Cellular and synaptic mechanisms underlying how chronic pain induces maladaptive
alterations to local circuits in the medial prefrontal cortex (mPFC), while emerging, remain …