Virological and immunological status of the people living with HIV/AIDS undergoing ART treatment in Nepal

CR Ojha, G Shakya, SP Dumre - BioMed research international, 2016 - Wiley Online Library
Antiretroviral therapy (ART) has increased the life span of the people living with HIV (PLHIV),
but their virological and immunological outcomes are not well documented in Nepal. The …

Accumulation of HIV-1 drug resistance after continued virological failure on first-line ART in adults and children in sub-Saharan Africa

TS Boender, CM Kityo, RS Boerma… - Journal of …, 2016 - academic.oup.com
Objectives Limited availability of viral load (VL) monitoring in HIV treatment programmes in
sub-Saharan Africa can delay switching to second-line ART, leading to the accumulation of …

Determinants of first line antiretroviral therapy treatment failure among adult patients on ART at central Ethiopia: un-matched case control study

D Mulisa, M Tesfa, G Mullu Kassa, T Tolossa - BMC Infectious Diseases, 2019 - Springer
Abstract Background In 2018 in Ethiopia, magnitude of human immunodeficiency virus
Acquired Immunodeficiency Syndrome treatment failure was 15.9% and currently the …

Effect of pretreatment HIV-1 drug resistance on immunological, virological, and drug-resistance outcomes of first-line antiretroviral treatment in sub-Saharan Africa: a …

RL Hamers, R Schuurman, KCE Sigaloff… - The Lancet infectious …, 2012 - thelancet.com
Background The effect of pretreatment HIV-1 drug resistance on the response to first-line
combination antiretroviral therapy (ART) in sub-Saharan Africa has not been assessed. We …

Baseline predictors of antiretroviral treatment failure and lost to follow up in a multicenter countrywide HIV-1 cohort study in Ethiopia

NF Telele, AW Kalu, G Marrone, S Gebre-Selassie… - PloS one, 2018 - journals.plos.org
Background Antiretroviral therapy (ART) has been rapidly scaled up in Ethiopia since 2005,
but factors influencing the outcome are poorly studied. We therefore analysed baseline …

Virological failure and HIV type 1 drug resistance profiles among patients followed-up in private sector, Douala, Cameroon

C Charpentier, F Talla, E Nguepi… - AIDS research and …, 2011 - liebertpub.com
The rate of virological failure was assessed in 819 patients followed up by the private sector
of Douala, the economic capital of Cameroon, and treated according to the World Health …

High viral load and multidrug resistance due to late switch to second-line regimens could be a major obstacle to reach the 90-90-90 UNAIDS objectives in sub …

E Guichet, A Aghokeng, L Serrano, G Bado… - AIDS Research and …, 2016 - liebertpub.com
In the context of lifelong antiretroviral treatment (ART) as early as possible and to end the
HIV/AIDS epidemic as a public health treat by 2030, it is important to evaluate the potential …

Importance of routine viral load monitoring: higher levels of resistance at ART failure in Uganda and Lesotho compared with Switzerland

N Bachmann, A von Braun, ND Labhardt… - Journal of …, 2019 - academic.oup.com
Objectives Emerging resistance to antiretroviral drugs may jeopardize the achievements of
improved access to ART. We compared the prevalence of different resistance mutations in …

High levels of dual-class drug resistance in HIV-infected children failing first-line antiretroviral therapy in Southern Ethiopia

BT Tadesse, NN Kinloch, B Baraki, HR Lapointe… - Viruses, 2018 - mdpi.com
Clinical monitoring of pediatric HIV treatment remains a major challenge in settings where
drug resistance genotyping is not routinely available. As a result, our understanding of drug …

Virological failure and associated risk factors among HIV/AIDS pediatric patients at the ART clinic of Jimma University Medical Center, Southwest Ethiopia

FT Osman, MA Yizengaw - The Open AIDS Journal, 2020 - benthamopen.com
Background: Pediatric antiretroviral treatment failure is an under-recognized issue that
receives inadequate attention in the field of pediatrics and within HIV treatment programs …