Chronic inflammation is associated with aging and plays a causative role in several age-
related diseases such as cancer, atherosclerosis and osteoarthritis. The source of this …

Inflammation acts as a double-edged sword in the pathogenesis of cancer. Inflammatory
responses play a key role in eliminating potentially cancerous cells; however, an …

Aging and cancer are highly correlated biological phenomena. Various cellular processes
such as DNA damage responses and cellular senescence that serve as tumor suppressing …

Senescent cells, albeit not proliferating, are metabolically and transcriptionally active,
thereby capable of affecting their microenvironment, notably via the production of …

Cellular senescence is a state of stable cell cycle arrest associated with macromolecular
alterations and secretion of proinflammatory cytokines and molecules. From their initial …

Cellular senescence entails a state of an essentially irreversible proliferative arrest in which
cells remain metabolically active and secrete a range of pro-inflammatory and proteolytic …

Cellular senescence is the arrest of normal cell division. Oncogenic genes and oxidative
stress, which cause genomic DNA damage and generation of reactive oxygen species, lead …

Cytokine dysregulation is believed to play a key role in the remodeling of the immune
system at older age, with evidence pointing to an inability to fine-control systemic …

Recent scientific studies have advanced the notion of chronic inflammation as a major risk
factor underlying aging and age-related diseases. In this review, low-grade, unresolved …

Cellular senescence is a proliferation arrest that is typically irreversible and caused by
various cellular stresses, including excess rounds of cell division and cancer-causing …