Inflammatory networks during cellular senescence: causes and consequences
Chronic inflammation is associated with aging and plays a causative role in several age-
related diseases such as cancer, atherosclerosis and osteoarthritis. The source of this …
related diseases such as cancer, atherosclerosis and osteoarthritis. The source of this …
Inflammatory signaling and cellular senescence
Inflammation acts as a double-edged sword in the pathogenesis of cancer. Inflammatory
responses play a key role in eliminating potentially cancerous cells; however, an …
responses play a key role in eliminating potentially cancerous cells; however, an …
[HTML][HTML] Cancer and aging-the inflammatory connection
A Zinger, WC Cho, A Ben-Yehuda - Aging and disease, 2017 - ncbi.nlm.nih.gov
Aging and cancer are highly correlated biological phenomena. Various cellular processes
such as DNA damage responses and cellular senescence that serve as tumor suppressing …
such as DNA damage responses and cellular senescence that serve as tumor suppressing …
Senescence-associated inflammatory responses: aging and cancer perspectives
A Lasry, Y Ben-Neriah - Trends in immunology, 2015 - cell.com
Senescent cells, albeit not proliferating, are metabolically and transcriptionally active,
thereby capable of affecting their microenvironment, notably via the production of …
thereby capable of affecting their microenvironment, notably via the production of …
A senescence-centric view of aging: implications for longevity and disease
Cellular senescence is a state of stable cell cycle arrest associated with macromolecular
alterations and secretion of proinflammatory cytokines and molecules. From their initial …
alterations and secretion of proinflammatory cytokines and molecules. From their initial …
Mechanisms and regulation of cellular senescence
L Roger, F Tomas, V Gire - International journal of molecular sciences, 2021 - mdpi.com
Cellular senescence entails a state of an essentially irreversible proliferative arrest in which
cells remain metabolically active and secrete a range of pro-inflammatory and proteolytic …
cells remain metabolically active and secrete a range of pro-inflammatory and proteolytic …
Cellular senescence: Molecular mechanisms and pathogenicity
W Wei, S Ji - Journal of cellular physiology, 2018 - Wiley Online Library
Cellular senescence is the arrest of normal cell division. Oncogenic genes and oxidative
stress, which cause genomic DNA damage and generation of reactive oxygen species, lead …
stress, which cause genomic DNA damage and generation of reactive oxygen species, lead …
Age and age-related diseases: role of inflammation triggers and cytokines
IM Rea, DS Gibson, V McGilligan… - Frontiers in …, 2018 - frontiersin.org
Cytokine dysregulation is believed to play a key role in the remodeling of the immune
system at older age, with evidence pointing to an inability to fine-control systemic …
system at older age, with evidence pointing to an inability to fine-control systemic …
Molecular inflammation: underpinnings of aging and age-related diseases
Recent scientific studies have advanced the notion of chronic inflammation as a major risk
factor underlying aging and age-related diseases. In this review, low-grade, unresolved …
factor underlying aging and age-related diseases. In this review, low-grade, unresolved …
Healing and hurting: molecular mechanisms, functions, and pathologies of cellular senescence
PD Adams - Molecular cell, 2009 - cell.com
Cellular senescence is a proliferation arrest that is typically irreversible and caused by
various cellular stresses, including excess rounds of cell division and cancer-causing …
various cellular stresses, including excess rounds of cell division and cancer-causing …