Antibiotic discovery is in crisis. Despite a growing need for new drugs resulting from the
increasing number of multi-antibiotic-resistant pathogens, there have been only a handful of …

Natural products and their derivatives are mainstays of our antibiotic drugs, but they are
increasingly in peril. The combination of widespread multidrug resistance in once …

New antibiotics are necessary to treat microbial pathogens that are becoming increasingly
resistant to available treatment. Despite the medical need, the number of newly approved …

Microbial natural products have been one of the most important sources for the discovery of
potential new antibiotics. However, the decline in the number of new chemical scaffolds …

The widespread emergence of antibiotic-resistant pathogens poses a severe threat to public
health. This problem becomes even worse with a coincident decline in the supply of new …

The spread of resistant organisms is producing a human health crisis, as we are witnessing
the emergence of pathogens resistant to all available antibiotics. An increase in chronic …

New classes of antibacterial compounds are urgently needed to respond to the high
frequency of occurrence of resistances to all major classes of known antibiotics. Microbial …

The problem of antibiotic resistance has become a challenge for our public health and
society; it has allowed infectious diseases to re-emerge as a risk to human health. New …

It has been nearly 50 years since the golden age of antibiotic discovery (1945–1975) ended;
yet, we still struggle to identify novel drug targets and to deliver new chemical classes of …

Due to the threat posed by the increase of highly resistant pathogenic bacteria, there is an
urgent need for new antibiotics; all the more so since in the last 20 years, the approval for …