The receptor tyrosine kinase c-Kit and its ligand Stem Cell Factor (SCF) are essential for
haemopoiesis, melanogenesis and fertility. SCF acts at multiple levels of the haemopoietic …

c-Kit is a receptor tyrosine kinase that binds stem cell factor (SCF). Structurally, c-Kit contains
five immunoglobulin-like domains extracellularly and a catalytic domain divided into two …

Many years ago, alert observers noticed among thousands of laboratory mice a few
individuals that, unlike their littermates, exhibited areas of white spotting on their fur. No one …

Publisher Summary This chapter focuses on the importance of stem cell factor (SCF) and the
stem cell factor receptor (SCFR) in hematopoiesis and other complex developmental …

Recombinant human stem cell factor (SCF) is homologous with recombinant rat SCF (rrSCF)
and is a ligand for c-kit. We determined the influence of SCF on hematopoiesis in vitro and in …

The receptor tyrosine kinase c-Kit is expressed in hematopoietic stem and progenitor cells
and in several non-hematopoietic tissues. In the hematopoietic system, c-Kit is critical for …

The proto-oncogene c-kit encodes a transmembrane tyrosine kinase receptor for stem cell
factor (SCF). The c-kit/SCF signal is expected to have an important role in hematopoiesis. A …

Stem cell factor (SCF) plays important roles in hematopoiesis and the survival, proliferation,
and differentiation of mast cells, melanocytes, and germ cells. SCF mediates its biological …

Stem cell factor (SCF) is a cytokine critical for normal hematopoiesis. The receptor for SCF is
c-Kit, a receptor tyrosine kinase. Our laboratory is interested in delineating critical …

The product of the c‐kit proto‐oncogene, denoted Kit/SCF‐R, encodes a tyrosine kinase
receptor for stem cell factor (SCF). Kit/SCF‐R induces proliferation, differentiation or …