Signaling Through the Interaction of Membrane-Restricted Stem Cell Factor and c-kit Receptor Tyrosine Kinase: Genetic Evidence for a Differential Role in …

R Kapur, M Majumdar, X Xiao… - Blood, The Journal …, 1998 - ashpublications.org
Mutations of the receptor tyrosine kinase c-kit or its ligand stem cell factor (SCF), which is
encoded as a soluble and membrane-associated protein by the Steel gene in mice, lead to …

Interaction of human bone marrow fibroblasts with megakaryocytes: role of the c-kit ligand

H Avraham, DT Scadden, S Chi, VC Broudy, KM Zsebo… - 1992 - ashpublications.org
Human kit ligand (KL), also known as stem cell factor (SCF), steel factor, or mast cell growth
factor, is a recently identified hematopoietic growth factor whose receptor is the product of …

[HTML][HTML] STAT protein recruitment and activation in c-Kit deletion mutants

MF Brizzi, P Dentelli, A Rosso, Y Yarden… - Journal of Biological …, 1999 - ASBMB
Stem cell factor (SCF) and its tyrosine kinase receptor, c-Kit, play a crucial role in regulating
migration and proliferation of melanoblasts, germ cells, and hemopoietic cell progenitors by …

Effects of the stem cell factor, c-kit ligand, on human megakaryocytic cells

H Avraham, E Vannier, S Cowley, SX Jiang, S Chi… - 1992 - ashpublications.org
The kit ligand (KL), also termed stem cell factor (SCF), is a recently discovered
hematopoietic growth factor that augments response of early progenitor cells to other growth …

Stem cell factor (SCF), a novel hematopoietic growth factor and ligand for c-kit tyrosine kinase receptor, maps on human chromosome 12 between 12q14.3 and …

EN Geissler, M Liao, JD Brook, FH Martin… - Somatic cell and …, 1991 - Springer
Recently a novel hematopoietic growth factor, stem cell factor (SCF), was cloned and
demonstrated to be the ligand for the c-kit tyrosine kinase receptor. In the mouse, SCF is …

Effects of human stem cell factor (c-kit ligand) on proliferation of myeloid leukemia cells: heterogeneity in response and synergy with other hematopoietic growth …

T Pietsch, U Kyas, U Steffens, E Yakisan, MR Hadam… - 1992 - ashpublications.org
A novel hematopoietic growth factor, the stem cell factor (SCF), for primitive hematopoietic
progenitor cells has recently been purified and its gene has been cloned. In this study we …

Regulation of Mouse and Human Mast Cell Development, Survival and Function by Stem Cell Factor, the Ligand for the c-kit Receptor

SJ Galli, M Tsai, BK Wershil, SY Tam… - International archives of …, 1995 - karger.com
Stem cell factor (SCF), the ligand for the receptor (SCFR) that is encoded by the c-kit proto-
oncogene, has many important effects in mouse and human mast cell development, survival …

Expression and function of c-Kit in fetal hemopoietic progenitor cells: transition from the early c-Kit-independent to the late c-Kit-dependent wave of hemopoiesis in the …

M Ogawa, S Nishikawa, K Yoshinaga… - …, 1993 - journals.biologists.com
The protooncogene c-kit encodes a receptor type tyro-sine kinase and is allelic with the W
locus of mice. SLF, the c-Kit ligand which is encoded by the Sl locus, has growth promoting …

Growth stimulation of colorectal carcinoma cells via the c‐kit receptor is inhibited by TGF‐β1

G Bellone, S Silvestri, E Artusio… - Journal of cellular …, 1997 - Wiley Online Library
Activation of the receptor tyrosine kinase c‐kit by the kit‐ligand, also known as stem cell
factor (SCF), is essential to melanocyte and germ cell development and during the early …

The rat c-kit ligand, stem cell factor, induces c-kit receptor-dependent mouse mast cell activation in vivo. Evidence that signaling through the c-kit receptor can induce …

BK Wershil, M Tsai, EN Geissler, KM Zsebo… - The Journal of …, 1992 - rupress.org
Interactions between products of the mouse W locus, which encodes the c-kit tyrosine kinase
receptor, and the Sl locus, which encodes a ligand for c-kit receptor, which we have …