The phenotypes of mice that harbor a defect in the genes encoding either stem cell factor
(SCF) or its receptor, c-kit, indicate that this ligand/receptor pair is necessary for …

Activation of the receptor tyrosine kinase c‐kit by the kit‐ligand, also known as stem cell
factor (SCF), is essential to melanocyte and germ cell development and during the early …

c-kit encodes the transmembrane receptor tyrosine kinase (Kit) for the recently described
ligand stem cell factor (SCF). We have developed an enzyme-linked immunosorbent assay …

The cell-surface receptor c-kit and its cognate ligand stem-cell factor (SCF) or steel factor
(SLF) are important for the maintenance of hematopoiesis both in vitro and in vivo …

The c-kit proto-oncogene encodes a receptor tyrosine kinase. Binding of c-kit ligand, stem
cell factor (SCF) to c-kit receptor (c-kitR) is known to activate c-kitR tyrosine kinase, thereby …

Stem cell factor (SCF) is a hematopoietic growth factor that interacts with the receptor
tyrosine kinase, c-kit. We have found that SCF-stimulates rapid and transient tyrosine …

Mice with W mutations characterized by hypopigmentation, sterility, anemia, and mast cell
deficiency have abnormalities in c-kit, a receptor with tyrosine kinase activity. Recently, the …

Signaling by stem cell factor and Kit, its receptor, plays important roles in gametogenesis,
hematopoiesis, mast cell development and function, and melanogenesis. Moreover, human …

Human stem cell factor (SCF) acts in the presence of other growth factors to stimulate the
growth of primitive hematopoietic progenitor cells. These effects are performed by activation …

Stem cell factor (SCF) binds the receptor tyrosine kinase c-Kit and is critical for normal
hematopoiesis. Substitution of valine for aspartic acid 816 (D816V) constitutively actives …